The National Eye Institute (NEI) awarded a $462,072 Project Grant under the Vision Research federal grant program (CFDA 93.867) to Tufts Medical Center Parent, Inc. (Tufts Medical Center) to study the metabolic basis of retinopathy of prematurity (ROP) and potential treatment with anaplerotic substrates. The project aims to investigate the fatty acid metabolic exchanges between the liver and retina at the systems level, and to use anaplerotic substrates in conjunction with adeno-associated viruses (AAVs) to genetically manipulate fatty acid metabolic genes in order to prevent oxygen-induced retinopathy. The award period runs from April 1, 2025 to March 31, 2030.
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