Project Grant R00EY033858
Award Date 9/15/25
Completion Date 8/31/28
Dollars Obligated $249K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Bloomington, IN 47405, USA
Similar Awards
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $431,750 Project Grant to the University of Louisville to study the role of neurexin proteins in retinal structure and function. The grant, effective from September 1, 2025 to August 31, 2027, aims to 1) determine the function of three neurexin genes and their isoform-specific expression patterns within the retina, and 2) characterize the cell-type-specific expression of neurexin isoforms...
- This federal Project Grant award of $206,739 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to develop a novel adeno-associated virus (AAV) gene therapy approach for treating inherited retinal diseases (IRDs). The key objectives are to test an innovative pre-retinal AAV administration method combined with insulin delivery to accelerate uptake of the gene therapy vector into retinal cells. This aims to address limitations with current...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) is funding research to develop an innovative gene therapy approach using self-amplifying and self-splicing RNA technologies. The $346,500 award, spanning September 2024 to September 2026, aims to evaluate the longevity, immunogenicity, and potential in vivo side effects of this novel mRNA-based therapy for treating inherited retinal dystrophies. The award recipient, The...
- The National Eye Institute (NEI) awarded a $437,310 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Rochester to conduct research on the molecular and physiological mechanisms of inner retinal remodeling in retinal degeneration. The research aims to elucidate the mechanisms behind genetic, morphological, and physiological changes in retinal ganglion cells that lead to decreased signal-to-noise ratio and corruption of retinal circuits, with the...
- The National Eye Institute (NEI), under its Vision Research federal grant program (CFDA 93.867), awarded a $431,750 Project Grant to the University of Houston System to develop a mutation-independent therapy for retinal degenerations caused by PRPH2 gene mutations. The two-year grant, awarded on August 1, 2025, aims to determine the applicability of a rhodopsin-specific antisense oligonucleotide (RHO-ASO) treatment to various PRPH2 mutation mouse models and investigate the efficacy of external...
- This $695,018 federal project grant awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to define how Müller glia (MG) cells, which function as injury-responsive stem cells, can enable retinal regeneration in zebrafish, mice, and potentially humans. The research aims to identify genes that regulate the regenerative potential of MG cells in the context of selective retinal cell loss, as occurs in degenerative eye diseases. By conducting...
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- This $1,369,974 Project Grant was awarded on September 15, 2025 by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to the West Virginia University Research Corporation (WVURC). The funding supports a 3-year research project to investigate therapies for defects in protein networks essential for the development of photoreceptor outer segments, a key component of photoreceptor neurons responsible for vision. The research aims to identify an optimal...
- The National Eye Institute (NEI) awarded a $431,750 Project Grant to the University of California, Irvine (UCI) to support research on "Amplified Femtosecond Laser Permeabilization and Poration for Nonviral Corneal Gene Delivery". The goal is to develop a novel, femtosecond laser-based approach to overcome barriers to topical gene therapy delivery to the cornea. This research aims to create microchannels through the corneal epithelium to enhance transepithelial diffusion and use...