This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), is funding the development of OPGX-RHO, a single-vector gene therapy for the treatment of autosomal-dominant retinitis pigmentosa (ADRP). The $882,971 award supports two key objectives: 1) completing chemistry, manufacturing, and controls for a clinical-grade batch of OPGX-RHO, including stability studies and device compatibility testing, and 2) conducting efficacy and...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), will fund research to understand the genetic causes of inherited retinal degenerations (IRDs), a group of rare blinding diseases. The $1,369,782 award to the Massachusetts Eye and Ear Infirmary will support two key research aims: Developing a high-throughput splicing assay to identify rare coding and non-coding variants that lead to splicing defects and contribute to the...
The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded Piximune Inc. a $306,814 Project Grant (CFDA 93.867 - Vision Research) to develop a gene-agnostic antibody-based treatment for retinitis pigmentosa (RP), a leading cause of inherited vision loss and blindness. The project aims to address the limitations of current RP therapies by developing a novel approach that augments natural mechanisms to eliminate toxic photoreceptor debris, thereby...
This $380,000 Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate the role of interphotoreceptor matrix proteoglycans in retinal homeostasis and retinitis pigmentosa. The project aims to: 1) Explore how the proteoglycans IMPG1 and IMPG2 facilitate nutrient exchange between the retina and retinal pigment epithelium, and how mutations in these molecules lead to adult-onset retinitis pigmentosa; 2) Determine...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) is funding research to develop an innovative gene therapy approach using self-amplifying and self-splicing RNA technologies. The $346,500 award, spanning September 2024 to September 2026, aims to evaluate the longevity, immunogenicity, and potential in vivo side effects of this novel mRNA-based therapy for treating inherited retinal dystrophies. The award recipient, The...
The U.S. National Eye Institute (NEI) awarded a $184,117 Project Grant (CFDA 93.867 - Vision Research) to Oakland University to determine the role of G-coupled protein receptors GPR31 and GPR39 in the pathogenesis of diabetic retinopathy. The project aims to investigate the affinities and substrate specificities of GPR31 and GPR39 for 12- and 15-HETE metabolites in retinal endothelial cells and Müller cells under normal and hyperglycemic conditions. It will also examine the effects of GPR31 or...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...
This Project Grant award of $620,149 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports a multi-center research program to develop advanced genome editing technologies for modifying critical genetic risk factors associated with age-related macular degeneration (AMD). The research team, led by the University of Iowa, will conduct base editing and prime editing of AMD risk loci in human cells, including induced pluripotent stem...
This federal Project Grant award, provided by the National Eye Institute (CFDA 93.867 Vision Research), supports research at the Whitehead Institute for Biomedical Research to systematically identify and characterize novel oxidative protective genes that can prevent retinal pigment epithelium (RPE) degeneration and age-related macular degeneration (AMD). The $173,016 award, effective from Aug 1, 2025 to Jul 31, 2027, will fund a project focused on three primary aims: 1) elucidating the...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to understand the molecular mechanisms that specify different subtypes of photoreceptor neurons for color vision. The $435,052 award to the University of Massachusetts Boston aims to elucidate how conserved transcription factors and cis-regulatory mechanisms control the spatially precise expression of opsins in specific photoreceptor neuron subtypes. The...