Project Grant K99AG090693
- This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into the molecular interplay of sleep and neurodegeneration using the Drosophila model system. With $2.14 million provided over 11 months, the Trustees of the University of Pennsylvania will investigate how expression of the TDP-43 protein linked to neurodegenerative diseases disrupts sleep in fruit flies. Researchers will aim to define the specific glial subtypes...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), is focused on assessing whether genetic risk variants for Alzheimer's disease (AD) have a pleiotropic effect on sleep. The primary objectives are to conduct in silico variant-to-gene mapping analysis to identify potential shared genetic factors underlying AD and sleep phenotypes, and to use CRISPR in zebrafish models to directly evaluate the impact of putative AD...
- This federal Project Grant award of $101,915 from the National Institute on Aging (CFDA 93.866 - Aging Research) is funding research to investigate the impacts of pharmacological slow wave sleep enhancement on cognition and memory in an Alzheimer's disease (AD) mouse model. The study, led by researchers at Columbia University, will use two drug compounds, gaboxadol and trazadone, to assess whether enhancing slow wave activity can normalize sleep-wake disturbances, reduce amyloid plaque burden,...
- This Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), provides $420,750 to Washington State University to investigate the complex interactions between aging, transcriptional processing, protein aggregation, sleep disturbance, and cognitive decline in an Alzheimer's disease rat model. The researchers will leverage innovative techniques, such as the use of single-chain variable fragments to evaluate protein oligomerization,...
- This $7.72 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Seattle Institute for Biomedical and Clinical Research will define the role of post-traumatic brain injury sleep disruption and glymphatic dysfunction in the development of Alzheimer's disease and chronic traumatic encephalopathy neuropathology. Over three years, the grantee and three sub-awardees will...
- The National Institute on Aging (NIA) awarded a $785,348 project grant (CFDA 93.866 - Aging Research) to The Salk Institute for Biological Studies in La Jolla, California. The project, titled "Chronic Sleep Disruption is a Stressor for Healthspan and Lifespan", will investigate the biological mechanisms by which chronic sleep disruption (CSD) may interact with the aging process to increase the risk of age-related diseases. The research aims to determine if long-term CSD affects the...
- This $612,005 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to characterize sleep slow-wave activity (SWA) and its relationship to chronic stress, accelerated aging, and Alzheimer's disease in a cohort of 200 Black older adults aged 55-80 in the United States. The award will support ambulatory overnight sleep monitoring, biomarker assessments, and cognitive testing to examine how chronic stress impacts SWA and its association with markers of...
- This $464,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "DIFFERENTIATING CHRONIC SLEEP DISRUPTION FROM INTERMITTENT HYPOXIA IN OSA ON TAU PATHOLOGY AND SPREAD" at the Icahn School of Medicine at Mount Sinai. The project aims to investigate the separate effects of chronic sleep disruption and intermittent hypoxia associated with obstructive sleep apnea (OSA) on the spread of tau pathology, a crucial step in...
- The National Institute on Aging (NIA) awarded Brigham & Women's Hospital Inc. a $2,576,936 Project Grant under the Aging Research federal grant program (CFDA 93.866) to characterize the variability in sleep spindle activity across a population and evaluate the use of sleep spindle dynamics as biomarkers for Alzheimer's disease, mild cognitive impairment, and trisomy 21. The 3-year project will develop statistical models and methods to analyze sleep spindle patterns and their relationship...
- This federal Project Grant award of $442,938, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research at the University of California, San Francisco (UCSF) to investigate the relationship between sleep, memory, and aging. The key objectives are to: 1) characterize how aging affects sleep patterns required for memory consolidation and synaptic plasticity during long-term memory formation; and 2) determine how upregulating the unfolded protein response can...
This federal Project Grant award of $125,000.00, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the relationship between sleep loss and neurodegeneration. The grantee, The Washington University, will use the funding to examine how sleep deprivation can epigenetically alter microglial responses to tau protein aggregates, which is a key pathological feature of Alzheimer's disease and other tauopathies. The research aims to identify mechanisms by which early sleep dysfunction may contribute to neurodegeneration, with the goal of developing interventions to mitigate the progression of these diseases. The project will leverage the university's expertise in neuroscience, immunology, and aging research, and is scheduled to run from September 15, 2025 through June 30, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 9/15/25 |