Project Grant R01AG096669
- Federal Grant Award Summary The National Institute on Aging awarded University of California, Irvine a $773,816 Project Grant under the Aging Research program (CFDA 93.866) on June 1, 2025, with a completion date of March 31, 2030. This award funds a multi-investigator research initiative investigating cell-type-specific and spatial proteogenomics analysis of aberrant RNA splicing and misfolded proteins in Alzheimer's-related tauopathies. The research team will generate single-cell spatial...
- Federal Project Grant Award Summary The University of California, Irvine received a $3.22 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with completion targeted for August 31, 2029. This award supports scientific research investigating the role of the retrosplenial cortex (RSC) in Alzheimer's disease (AD) pathogenesis. The research will deliver comprehensive findings on how neuronal hyperexcitability...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $107,097 to the Regents of the University of Michigan on September 16, 2025, under the Aging Research program (CFDA 93.866) to support scientific research examining the relationship between sleep disturbances and memory loss in aging populations. The project, titled "State-Dependent Gating of Memory and Plasticity in the Aging Brain," will be conducted through June 30, 2027, at the University of...
- Federal Project Grant Award Summary The National Institute on Aging awarded The Trustees of the University of Pennsylvania a $612,005 Project Grant (CFDA 93.866, Aging Research program) effective September 15, 2025, through July 31, 2030, to conduct research examining the relationship between sleep slow-wave activity (SWA), chronic stress, and Alzheimer's disease risk in Black older adults. The research will deliver comprehensive neurophysiological and biomarker assessments across two cohorts: a...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of California, Irvine $2.49M under the Aging Research program (CFDA 93.866) to conduct scientific research investigating circuit vulnerability in the entorhinal cortex during tauopathy-related Alzheimer's Disease (AD). The project, which commenced September 15, 2025, and extends through August 31, 2029, focuses on identifying neuronal cell types in the lateral and medial entorhinal cortex that are...
- Federal Grant Award Summary The National Institute on Aging awarded a $2.22 million Project Grant to the University of California, Irvine under the Aging Research program (CFDA 93.866) for the period September 1, 2025 through August 31, 2027. This award supports the development and optimization of enhancer adeno-associated virus (AAV) vectors—genetically engineered viral tools designed to provide cell-type-specific genetic access and manipulation capabilities in the brain. The primary...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded The Washington University a $125,000 project grant effective September 15, 2025, through June 30, 2027, under the Aging Research program (CFDA 93.866). This project grant supports scientific research investigating epigenetic modulations by sleep to mitigate neurodegeneration, with a specific focus on understanding the mechanistic relationship between sleep loss and tau protein aggregation in tauopathies, including...
- Federal Grant Award Summary The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai a $464,750 Project Grant under the Aging Research program (CFDA 93.866) on September 5, 2025, to support research investigating the mechanisms by which obstructive sleep apnea (OSA) contributes to Alzheimer's disease pathology. The research will differentiate the separate effects of chronic sleep disruption and intermittent hypoxia on tau pathology and spread throughout the brain, with...
- Federal Grant Award Summary The Salk Institute for Biological Studies received a $785,348 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on August 15, 2025, with a completion date of July 31, 2027. This award supports fundamental biomedical research investigating the relationship between chronic sleep disruption (CSD) and biological aging mechanisms. The research project examines how prolonged CSD affects healthspan and lifespan...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $412,500 Project Grant to the University of South Florida (USF) under the Aging Research program (CFDA 93.866) for a two-year research initiative running from June 1, 2025, through May 31, 2027. This grant funds scientific research aimed at identifying novel biomarkers for early diagnosis and prognosis prediction of Alzheimer's disease (AD), a neurodegenerative condition affecting 5.5 million Americans. The project...
The National Institute on Aging awarded a $619,099 Project Grant to the University of California, Irvine under the Aging Research program (CFDA 93.866) on February 1, 2026, for a five-year project period concluding January 31, 2031. This research initiative investigates longitudinal relationships between Alzheimer's disease (AD) pathophysiology, local sleep expression, and sleep-dependent memory across preclinical disease stages. The project delivers scientific research services employing an innovative multimodal neuroimaging design that combines polysomnography, high-density electroencephalography, and high-resolution structural magnetic resonance imaging to characterize medial temporal lobe neurite density and structural volume, supplemented by fluid biomarkers. The research addresses a critical knowledge gap by providing the first longitudinal characterization of how local sleep deficits evolve as amyloid-beta plaques, brain inflammation, and tau tangles accumulate in the brain prior to clinical symptom onset. The findings will isolate biological mechanisms linking local sleep expression with the progression of AD pathophysiology and cognitive impairment, potentially identifying sleep disturbance as a modifiable risk factor for disease prevention and treatment. This research contributes to the National Institute on Aging's mission to support biomedical research and training directed toward understanding aging processes and preventing or treating Alzheimer's disease and related dementias.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $619.1k | 1/26/26 |