Project Grant K99HD119295
- Summary The National Institute of Child Health and Human Development awarded a $119,544 Project Grant to The Washington University (Office of Sponsored Research Services) for research investigating the role of cell-free mitochondria in breast milk to support neonatal metabolism. The award was obligated on June 1, 2026, with an ultimate completion date of May 31, 2028. Funded under CFDA 93.865 (Child Health and Human Development Extramural Research), this investigator-initiated research project...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development awarded a $470,816 Project Grant to The Pennsylvania State University for the period June 1, 2026 through May 31, 2028 under the Child Health and Human Development Extramural Research program (CFDA 93.865). This research project investigates the molecular and metabolic mechanisms underlying secretory activation and milk volume production in mothers with infants in the Neonatal Intensive Care Unit (NICU). The...
- The National Institute of Child Health and Human Development (NICHD) awarded a $451,000 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Regents of the University of California, San Francisco (UCSF) to investigate the therapeutic potential of maternal breast milk components for preterm white matter injury (WMI). The key objectives are to: 1) Perform high-throughput screening of breast milk components to identify pro-myelinating compounds, and 2) Test...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $751,204 under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate the genetic and genomic mechanisms underlying human lactation disorders. The award, effective June 1, 2026 through May 31, 2031, funds comprehensive whole exome sequencing (WES) research...
- New York University School of Medicine received a $156,080 Project Grant award effective January 1, 2026, through August 31, 2028, from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research investigates the neurobiological mechanisms by which postpartum sickness impacts maternal caregiving behaviors, with particular focus on how inflammatory stress disrupts neuropeptidergic...
- Federal Grant Award Summary The National Institute of Child Health and Human Development awarded a $448,182 Project Grant to The Research Foundation For The State University Of New York (SUNY at Binghamton) under the Child Health and Human Development Extramural Research program (CFDA 93.865) for a project period from September 1, 2025 through March 31, 2027. The award funds the development of a novel physiologically based pharmacokinetic (PBPK) modeling approach to improve prediction of...
- Federal Grant Award Summary The National Institute of Child Health and Human Development awarded The Medical University of South Carolina a $183,168 Project Grant (CFDA 93.865 – Child Health and Human Development Extramural Research) effective June 4, 2026, with completion scheduled for May 31, 2029. The grant funds research investigating lipid degradation in human donor milk and its impact on preterm infant gastrointestinal outcomes, specifically necrotizing enterocolitis (NEC). The research...
- Federal Grant Award Summary Cornell University received a $1,494,000 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 15, 2025, with completion targeted for August 31, 2028. The award funds research to evaluate breast pumping protocol efficiency and elucidate the molecular and cellular mechanisms underlying enhanced milk production. This...
- This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a comparative study investigating the mechanistic effects of human milk feeding on neurodevelopment in preterm infants. The $239,399 award to the Regents of the University of Idaho will utilize a neonatal piglet model to examine how human milk feeding influences intestinal barrier function,...
- The National Science Foundation Division of Industrial Innovation awarded a $256,000 Project Grant to The Natural Nipple Corp. of Tampa, FL for its "NOVEL INFANT FEEDING SYSTEM FOR BREASTFEEDING SUPPORT AND BIOFEEDBACK ANALYSIS" proposal. Under this award, The Natural Nipple Corp. will develop a novel infant feeding system that provides breastfeeding support and biofeedback analysis. The system aims to support mothers through the breastfeeding process and analyze infant feeding...
MILK EXCRETION AND MYOEPITHELIAL CELL CONTRACTILITY: MODULATION BY THE NA+-ACTIVATED K+ CHANNELS, SLO2.1. - ABSTRACT BREASTFEEDING IS ESSENTIAL FOR REDUCING INFANT MORTALITY AND IMPROVING MATERNAL AND CHILD HEALTH. YET, FEWER THAN 25% OF U.S. INFANTS ARE EXCLUSIVELY BREASTFED FOR THE RECOMMENDED SIX MONTHS, WITH DELAYED LACTATION INITIATION AND INSUFFICIENT MILK PRODUCTION AMONG THE LEADING CAUSES FOR EARLY CESSATION. EFFECTIVE MILK EJECTION REQUIRES CONTRACTION OF MAMMARY MYOEPITHELIAL CELLS (MYOECS) IN RESPONSE TO OXYTOCIN (OT), BUT THE MOLECULAR MECHANISMS REGULATING MYOECS EXCITABILITY AND CONTRACTILITY DURING LACTATION REMAIN POORLY UNDERSTOOD. THIS PROJECT AIMS TO DEFINE HOW NA-ACTIVATED K CHANNELS (SLO2.1) MODULATE MYOECS EXCITABILITY, INTRACELLULAR CA2 SIGNALING, AND CONTRACTILE RESPONSES TO OXYTOCIN AT DIFFERENT LACTATION STAGES. I HYPOTHESIZE THAT SLO2.1 REGULATES MEMBRANE POTENTIAL (VM), AND THAT ITS ACTIVITY IS ESSENTIAL FOR PROPER MILK EJECTION AND LACTATION MAINTENANCE. PRELIMINARY DATA SHOW THAT MYOECS EXCITABILITY INCREASES NEAR DELIVERY, PEAKS POSTPARTUM, AND DECLINES AFTER WEANING, SUGGESTING STAGE-DEPENDENT ION CHANNEL REGULATION. ADDITIONALLY, SLO2.1 IS EXPRESSED IN MYOECS, ANDSIGNALING MODULATES VM AND [CA2] VIA MECHANISMS CONSISTENT WITH SLO2.1 ACTIVITY. DURING THE K99 PHASE, I WILL FIRST CHARACTERIZE THE VM AND CA2 DYNAMICS OF MYOECS ACROSS FOUR PHYSIOLOGICAL STAGES USING LIVE-CELL IMAGING AND ELECTROPHYSIOLOGY. SECOND, I WILL DEFINE THE ROLE OF SLO2.1 IN SETTING VM AND REGULATING MYOECS RESPONSIVENESS TOUSING KNOCKOUT MODELS, GENE EXPRESSION ASSAYS, AND FUNCTIONAL CONTRACTILITY MEASUREMENTS. THIRD, I WILL ASSESS THE IMPACT OF SLO2.1 LOSS ON MILK EJECTION AND PUP VIABILITY IN VIVO. THESE STUDIES WILL BE EXPANDED IN THE R00 PHASE, WHERE I WILL ESTABLISH AND VALIDATE A 3D MAMMARY GLAND ORGANOID MODEL USING WILD-TYPE AND SLO2.1-DEFICIENT TISSUE. THIS MODEL WILL ALLOW DETAILED STUDY OF VM, CA2, AND CONTRACTILITY DURING LACTATION TRANSITIONS. FINALLY, I WILL TEST HOW SLO2.1 AFFECTS ORGANOID RESPONSES TO OXYTOCIN AND PKC PATHWAY ACTIVATORS. THIS RESEARCH WILL UNCOVER MOLECULAR MECHANISMS CONTROLLING MAMMARY GLAND EXCITABILITY AND PROVIDE A PLATFORM FOR DEVELOPING THERAPIES TO SUPPORT BREASTFEEDING.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 6/15/26 | ||
| Not listed | $125.1k | 6/8/26 |