Project Grant R21HD115866
- This Project Grant award of $747,000.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to evaluate breast pumping protocols and elucidate the molecular and cellular mechanisms underlying enhanced milk production. The research aims to address critical issues around suboptimal breastfeeding practices, which result in significant public health...
- This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $154,796 to the Massachusetts Institute of Technology (MIT) to develop a biomimetic lactating mammary lobe system. The objective is to create an in vitro model that faithfully mirrors breast milk synthesis processes and can be used as a screening testbed to evaluate the safety of drugs and...
- This Project Grant award of $190,163 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports the development of the Utah Pediatric Clinical Pharmacology Training Program at the University of Utah. The program aims to train a diverse, highly skilled workforce in pediatric and maternal clinical pharmacology research to address critical knowledge gaps in safe and effective drug dosing...
- This $768,256 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to conduct a randomized controlled trial to reduce postpartum smoking relapse by promoting breastfeeding. The grant will enroll 280 pregnant mothers who successfully quit smoking during pregnancy, randomizing them into either a breastfeeding intervention group or an attention control group. The...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $167,400.00 to Brigham & Women's Hospital Inc. to conduct research on the effects of maternal micronutrient supplementation during lactation on infant neurodevelopment. The key objectives are to: 1) Determine if maternal multiple micronutrient supplementation during lactation...
- This $160,056 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to optimize antibiotic use and improve understanding of developmental pharmacokinetics in newborn infants. The key objectives are to: (1) quantify maternal antibiotic concentrations (ampicillin, gentamicin, vancomycin, clindamycin) in maternal and umbilical cord blood; and (2) perform...
- The National Institute of Child Health and Human Development (NICHD) awarded a $657,909 Project Grant under the Child Health and Human Development Extramural Research (CFDA 93.865) program to the Joslin Diabetes Center, Inc. in Boston, Massachusetts. The grant funds a research project to systematically investigate the effects of maternal exercise during lactation on the composition of human breast milk and the subsequent metabolic impacts on infants. The research aims to measure changes in...
- The National Institute of Child Health and Human Development (NICHD), part of the U.S. Department of Health and Human Services, awarded a $655,674 Project Grant to the University of Colorado-Denver under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant, awarded on July 24, 2025, will support research investigating the role of lipid droplet docking in lactation initiation and milk secretion. The proposed studies use mouse models, imaging techniques,...
- The National Institute of Child Health and Human Development (NICHD) awarded a $451,000 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Regents of the University of California, San Francisco (UCSF) to investigate the therapeutic potential of maternal breast milk components for preterm white matter injury (WMI). The key objectives are to: 1) Perform high-throughput screening of breast milk components to identify pro-myelinating compounds, and 2) Test...
- The U.S. National Institute of Child Health and Human Development (NICHD) awarded a Project Grant of $428,208 to The Pennsylvania State University (Penn State) on September 12, 2025 under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The project aims to demonstrate the use of casein proteins from bovine milk to create amorphous solid dispersions (ASD) of insoluble active pharmaceutical ingredients (APIs) for oral liquid formulations targeting...
This Project Grant award of $448,182 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to develop a novel physiologically based pharmacokinetic (PBPK) modeling approach to improve predictions of drug transfer into breast milk. The research seeks to address the significant safety concerns around medication use by breastfeeding women, as studies show they use an average of three different medicines during lactation. The project will leverage the researchers' prior work, including developing an in vitro to in vivo extrapolation (IVIVE) approach for predicting milk-to-plasma ratios and a human normal mammary epithelial cell-based permeability assay, to create a more robust PBPK modeling approach. This will incorporate the impact of efflux transporters like breast cancer resistance protein (BCRP) to generate more accurate predictions of drug pharmacokinetics in breast milk. The ultimate goal is to improve the ability to ensure the safe use of medications for lactating mothers.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $448.2k | 8/27/25 |