Project Grant K99GM160792
- This $431,614 project grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the biochemical and structural mechanisms of alpha/beta tubulin biogenesis and microtubule polymerization regulators, and their impact on microtubule function. The research aims to advance the understanding of the cellular regulation pathways governing the dynamic microtubule...
- This Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $327,019 award supports research to elucidate how cell motion and mechanical forces affect intercellular signaling and cell fates during embryonic development and tissue formation. The University of California, San Diego (UCSD) is conducting this 5-year project to develop biophysical principles and data-driven methods...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- This federal Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $849,969 to the University of Cincinnati to investigate the interplay between the allosteric properties of microtubule lattices and protein-protein interactions that impact neuronal function. The project aims to use multi-scale computational modeling and machine learning, complemented by experimental testing, to provide quantitative insight into how changes in...
- The Project Grant award of $528,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to reveal the molecular basis of microtubule-intermediate filament interactions. The research will focus on understanding how microtubules and neurofilaments, which are key cytoskeletal components in myelinated axons, are adapted to form specialized cytoskeletal arrays that regulate cell shape and...
- This $427,625.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the molecular mechanisms of compound microtubule structure and function within the mammalian centrosome-cilium complex. The research aims to elucidate how specialized triplet and doublet microtubules, formed with the key proteins delta-tubulin and epsilon-tubulin, contribute to the...
- This federal Project Grant award of $249,000.00 was made on September 1, 2025 under the Biomedical Research and Research Training program (CFDA 93.859), administered by the National Institute of General Medical Sciences (NIGMS). The grant supports research aimed at determining how biophysical cues, such as matrix viscoelasticity, shape the behavior and interactions of macrophages and T-cells within the tumor microenvironment. The University of California, San Diego (UCSD) is the awardee, with...
- This $414,285 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research into the dynamic pattern formation and self-organizing behaviors of the cell cortex. The research aims to elucidate the principles underlying cortical reorganization processes that drive critical cellular functions like cell division, locomotion, and damage response. The primary awardee is the...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $651,001.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the structural and biochemical mechanisms of microtubule dynamics and regulation. The research aims to advance the fundamental understanding of how the conformational cycle and allosteric properties of tubulin subunits dictate the...
- This $640,500 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support research to investigate the role of microtubule allostery and mimicry in regulating tubulin post-translational modifications. The project, conducted by the University of New Mexico (UNM) Health Sciences Center, aims to deepen the understanding of how microtubule conformational states and interactions with...
This federal Project Grant award of $125,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project at the University of California, San Diego (UCSD) to investigate how microtubule dynamics are regulated at the cellular cortex, the interface between the plasma membrane and cytoskeleton. The primary objectives of the project are to: 1) Examine the mechanisms by which the cortical protein EFA-6 undergoes phase separation to modulate microtubule dynamics, and 2) Identify and characterize novel cortical microtubule regulators and their roles in membrane-related functions. The research will use the C. elegans model organism to leverage its well-characterized microtubule dynamics, genetic tractability, and live-cell imaging capabilities. This research aims to provide new insights into microtubule homeostasis and inform the treatment of diseases associated with microtubule dysfunction, such as microcephaly, ALS, and Parkinson's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 7/28/25 |