Project Grant R01GM157298
- This Project Grant award of $222,708.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to define the mechanisms by which individual microtubules are identified and chosen in cells for specific post-translational modifications. The research aims to determine how cells utilize mechanical cues to drive microtubule modifications and how these cues may be altered to impact cellular...
- This $431,614 project grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the biochemical and structural mechanisms of alpha/beta tubulin biogenesis and microtubule polymerization regulators, and their impact on microtubule function. The research aims to advance the understanding of the cellular regulation pathways governing the dynamic microtubule...
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $651,001.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the structural and biochemical mechanisms of microtubule dynamics and regulation. The research aims to advance the fundamental understanding of how the conformational cycle and allosteric properties of tubulin subunits dictate the...
- This $427,625.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the molecular mechanisms of compound microtubule structure and function within the mammalian centrosome-cilium complex. The research aims to elucidate how specialized triplet and doublet microtubules, formed with the key proteins delta-tubulin and epsilon-tubulin, contribute to the...
- This federal Project Grant award of $350,275.00 was provided by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), with a performance period from July 1, 2025 to June 30, 2030. The grant supports a research project at the University of New Mexico (UNM) Health Sciences Center that aims to investigate the molecular mechanisms by which extracellular glucose levels regulate cell mechanics and function. The research...
- The Project Grant award of $528,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to reveal the molecular basis of microtubule-intermediate filament interactions. The research will focus on understanding how microtubules and neurofilaments, which are key cytoskeletal components in myelinated axons, are adapted to form specialized cytoskeletal arrays that regulate cell shape and...
- This federal Project Grant award, valued at $2,094,250 and administered by the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 (Biomedical Research and Research Training), supports research at the University of New Mexico (UNM) into the interactions between the methionine cycle and coronavirus RNA capping mechanisms. The research aims to elucidate the spatiotemporal regulation and quaternary structures of enzyme complexes involved in the methionine cycle, which...
- This federal Project Grant award of $125,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project at the University of California, San Diego (UCSD) to investigate how microtubule dynamics are regulated at the cellular cortex, the interface between the plasma membrane and cytoskeleton. The primary objectives of the project are to: 1) Examine the mechanisms by...
- The National Institute of General Medical Sciences (NIGMS) awarded a $2,041,875 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Board of Regents of the University of Nebraska. The project aims to utilize cutting-edge live-cell single molecule tracking, super-resolution microscopy, and CRISPR-Cas9 gene editing technologies to unravel the regulation of the Arp2/3 actin assembly complex and its role in cellular processes such as lamellipodial...
This $640,500 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support research to investigate the role of microtubule allostery and mimicry in regulating tubulin post-translational modifications. The project, conducted by the University of New Mexico (UNM) Health Sciences Center, aims to deepen the understanding of how microtubule conformational states and interactions with microtubule-associated proteins affect the accessibility and modification of tubulin C-terminal tails. The research will utilize biosensors developed by the investigators to visualize these processes in vitro and in cells, with the goal of potentially reshaping the "tubulin code" theory. The award period runs from September 30, 2025 to September 29, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $640.5k | 9/10/25 |