Project Grant R35GM158334
- This $640,500 project grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will support research to investigate the role of microtubule allostery and mimicry in regulating tubulin post-translational modifications. The project, conducted by the University of New Mexico (UNM) Health Sciences Center, aims to deepen the understanding of how microtubule conformational states and interactions with...
- This $427,625.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the molecular mechanisms of compound microtubule structure and function within the mammalian centrosome-cilium complex. The research aims to elucidate how specialized triplet and doublet microtubules, formed with the key proteins delta-tubulin and epsilon-tubulin, contribute to the...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $651,001.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the structural and biochemical mechanisms of microtubule dynamics and regulation. The research aims to advance the fundamental understanding of how the conformational cycle and allosteric properties of tubulin subunits dictate the...
- This Project Grant award of $222,708.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to define the mechanisms by which individual microtubules are identified and chosen in cells for specific post-translational modifications. The research aims to determine how cells utilize mechanical cues to drive microtubule modifications and how these cues may be altered to impact cellular...
- This federal Project Grant award of $125,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project at the University of California, San Diego (UCSD) to investigate how microtubule dynamics are regulated at the cellular cortex, the interface between the plasma membrane and cytoskeleton. The primary objectives of the project are to: 1) Examine the mechanisms by...
- The Project Grant award of $528,000.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research to reveal the molecular basis of microtubule-intermediate filament interactions. The research will focus on understanding how microtubules and neurofilaments, which are key cytoskeletal components in myelinated axons, are adapted to form specialized cytoskeletal arrays that regulate cell shape and...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- This federal Project Grant award of $380,070.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "ACTIVE CHROMOSOME MOVEMENT IN MEIOTIC PAIRING" at the University of California, San Francisco (UCSF). The project aims to investigate the cellular mechanism of meiotic pairing, testing hypotheses regarding the role of telomere-led active motion and nuclear...
- The University of California, Davis received a $435,769 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). This 5-year grant, awarded on September 1, 2025, supports the university's research efforts to uncover the physical principles that define the function of the cellular glycocalyx. The key objectives are to develop novel imaging tools, computational models, and genetic engineering...
This $431,614 project grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the biochemical and structural mechanisms of alpha/beta tubulin biogenesis and microtubule polymerization regulators, and their impact on microtubule function. The research aims to advance the understanding of the cellular regulation pathways governing the dynamic microtubule cytoskeleton, which is critical for intracellular organization, cell division, and trafficking. The project will use a range of methods including in vitro reconstitution of purified assemblies and structural studies by cryo-electron microscopy. The award was granted to the University of California, Davis, a prominent public research university, and the project period extends from August 1, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $431.6k | 7/28/25 |