Project Grant R35GM160185

Award Date 8/1/25
Completion Date 7/31/30
Dollars Obligated $428K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
University City, MO 63130, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $651,001.00 to The University of Texas Southwestern Medical Center (UT Southwestern) to investigate the structural and biochemical mechanisms of microtubule dynamics and regulation. The research aims to advance the fundamental understanding of how the conformational cycle and allosteric properties of tubulin subunits dictate the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $471,625 in funding to the Marine Biological Laboratory (MBL) to advance research on the mechanisms that control epithelial tube development, orientation, and integrity. The project aims to expand understanding of fundamental processes that guide the organization and function of epithelial tissues, which form the building...
This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) will support research into the coordination and force transmission of beating cilia. Cilia are tiny, slender structures that extend from cells and play a critical role in moving fluids in the lungs, brain, and reproductive systems. The $284,857 award, effective March 1, 2025 through February 29, 2028, will fund research at Washington University in St. Louis to study how cilia coordination is...
The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded Emory University a $724,356 Project Grant under the Biological Sciences program (CFDA 47.074) to investigate the role of the protein ARL13B in controlling ciliary cyclic AMP (cAMP) signaling. The research aims to unravel the ciliary cAMP "signature", optogenetically stimulate cAMP signaling within normal and ARL13B-excluded cilia, investigate the role of ciliary cAMP signaling in remodeling...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $250,000 in funding to The Trustees of Princeton University to conduct research on microtubule nucleation and its role in building dendrite architecture. The research aims to elucidate how microtubules self-organize into the micron-scale mitotic spindle structure, and to identify spindle assembly factors that contribute to the formation...
The National Institute of General Medical Sciences (NIGMS) awarded a $388,750 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Washington to conduct research on the biophysical mechanisms underlying Drosophila renal tubule morphogenesis. The research program aims to understand how cells coordinate to build and sculpt the complex 3D architecture of epithelial tubular structures, which is essential for organ function. The project will focus on...
This $402,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a novel approach that combines modular fluorophores and correlative super-resolution microscopy to investigate the structure, dynamics, and interactome of biomolecular condensates in bacteria. The project, being conducted at New York University, will apply this "opto-proteomic toolbox" to understand the role of...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), provides $421,999.00 to Emory University to investigate the mechanisms of RNA localization and centrosome regulation. The overarching goal is to understand how post-transcriptional mechanisms, such as local RNA and on-site translational control, influence centrosome activity and function. The research program aims to...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (ORIP) under CFDA 93.351 will support the development of a novel resource to investigate the ciliary proteome composition in different cell types and under varying conditions. The $222,750 award to the University of Alabama at Birmingham will enable the use of an engineered BirA*G3-B9D1 protein system to enable temporal and cell type-specific biotin labeling of proteins traversing the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $440,454 to The Washington University to study epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The project will investigate how epithelial cells sense and respond to extracellular matrix properties, force transmission, and nuclear mechanosensing in the context of processes like wound...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $427,625 in funding to The Washington University to conduct research on the molecular mechanisms underlying the structure and function of the mammalian centrosome-cilium complex.

The key objectives of this 5-year project are to: 1) determine how delta-tubulin and epsilon-tubulin form and stabilize the compound microtubules within the centrosome and cilia, 2) define the process of compound microtubule elongation, and 3) elucidate how these specialized microtubules scaffold the centrosome-cilium complex. This research aims to provide mechanistic insights into the assembly of these critical cellular structures and improve understanding of their dysregulation in diseases such as cancer, microcephaly, and ciliopathies. The project will leverage advanced techniques including expansion microscopy, CRISPR/Cas9 gene editing, biochemistry, and proteomics.

Generated 8/5/25, 6:00 AM