Project Grant K99EY038871
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $481,500 under the Vision Research program (CFDA 93.867) to the University of California, Berkeley, effective September 1, 2025, through August 31, 2026. This award funds research investigating the role of retinal waves in vascular development, specifically examining neural-glial-vascular signaling mechanisms that influence blood vessel formation in the eye. The research directly addresses...
- Federal Grant Award Summary The University of California, San Francisco received a $255,340 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded May 1, 2026, with a completion date of April 30, 2031. This career development award supports research into the development and regeneration of retinal ganglion cells (RGCs) in the vertebrate retina, with the ultimate goal of developing therapeutic strategies to restore vision lost to glaucoma...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $130,182 to The Regents of the University of California, San Francisco (UCSF) under the Vision Research program (CFDA 93.867) for a project beginning April 1, 2026 and concluding March 31, 2028. This research grant supports neuroscience investigation into the identity and functional characteristics of neurons receiving bottom-up and top-down sensory inputs in primary visual cortex (V1) during both adult and...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $902,000 Project Grant to The Regents of the University of California, San Francisco, effective September 1, 2025, through August 31, 2027, under the Vision Research program (CFDA 93.867). This award supports research to develop and characterize a novel inherited mouse model of primary open-angle glaucoma (POAG), a leading cause of irreversible blindness affecting over 80 million people worldwide. The research utilizes...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $128,610 to the University of California, San Diego under the Vision Research program (CFDA 93.867) to conduct research on glaucoma pathogenesis and potential therapeutic interventions. The project, initiated December 1, 2025 and scheduled for completion by May 18, 2029, will deliver fundamental research findings elucidating the role of Thousand and One (TAO) kinases in retinal ganglion cell (RGC) death following axon...
- Federal Project Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded a $624,743 Project Grant to the University of California, Berkeley, effective May 1, 2026 through April 30, 2030. This award funds research investigating the physiological and neuroprotective roles of prostaglandin D2 (PGD2) and DP receptor signaling in retinal health and neurodegeneration. The research employs complementary methodologies including single-cell and bulk RNA...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $255,722 Project Grant to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027, under the Vision Research program (CFDA 93.867). This award supports research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The project will deliver empirical research findings examining how lipoxin B4 (LXB4), a neuroprotective molecule produced by retinal...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $125,954 Project Grant to The Regents of The University of California, Berkeley, effective July 1, 2026, through June 30, 2028. This award supports fundamental research investigating the molecular mechanisms underlying synaptic specificity in the retinal direction-selective circuit, a neural pathway critical for motion detection and visual stabilization. The research employs...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $134,106 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 15, 2025, with completion targeted for August 31, 2027. This award supports research aimed at elucidating the neural mechanisms by which the mammalian visual cortex stabilizes locomotion through visual feedback. The research addresses a significant gap in understanding...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded the University of California, Davis $423,767 under the Vision Research program (CFDA 93.867) for a two-year project period beginning June 1, 2025 and concluding May 31, 2027. The research project investigates the role of myeloid cells as mediators of glaucomatous axon degeneration and evaluates whether nicotinamide adenine dinucleotide (NAD+)-boosting interventions provide neuroprotection through anti-inflammatory...
The National Eye Institute (NEI) awarded $127,180 under the Vision Research program (CFDA 93.867) to The Regents of the University of California, San Francisco for a two-year project spanning July 1, 2026 through June 30, 2028. This Project Grant funds research investigating the role of perivascular retinal ganglion cells (RGCs) in regulating retinal vascular architecture and neurovascular resilience. The primary research products will include empirical findings on how a specialized subset of RGCs marked by FAM19A4/NTS and expressing the mechanosensitive ion channel PIEZO2 guides blood vessel formation and maintenance in the retina through mechanosensitive signaling pathways. The research comprises two specific aims designed to generate foundational scientific knowledge applicable to vision preservation. Aim 1 will produce data characterizing how perivascular RGCs shape three-dimensional retinal vascular architecture during development and identifying endothelial pathways affected by PIEZO2 signaling through staged manipulation of PIEZO2 activity. Aim 2 will deliver research findings evaluating whether PIEZO2-mediated signaling maintains vascular and neuronal integrity under pathological conditions, specifically in glaucoma and retinal ischemia disease models. The innovation of this research lies in elucidating neuron-to-vessel communication mechanisms, with anticipated outputs potentially identifying new therapeutic targets to prevent vision loss and improve treatment strategies for vascular-related ocular diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $5.4k | 6/17/26 | ||
| Not listed | $121.8k | 6/10/26 |