Project Grant K99EB039764
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded $754,366 to The Trustees of Columbia University in the City of New York on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the immunotherapeutic potential of probiotic extracellular vesicles as a therapeutic platform for immune dysregulation diseases. The research will elucidate molecular and cellular mechanisms by which probiotic extracellular...
- The National Cancer Institute, part of the Department of Health and Human Services, awarded The Trustees of Columbia University in the City of New York $635,722 on July 23, 2026, under the Cancer Treatment Research program (CFDA 93.395) to advance probiotic-guided CAR-T cell therapy toward clinical application. The project, titled "Advancing ProCAR Therapy Toward Clinical Application," addresses limitations in current engineered cell therapies for treating solid tumors. Specifically,...
- The National Center for Complementary and Integrative Health, a component of the Department of Health and Human Services National Institutes of Health, awarded Regents of the University of Michigan $546,000 on August 15, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for Project Grant R61AT013720. The award funds a two-phase investigation into precision probiotics engineered to support lactate metabolism and organ recovery in hospitalized...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $107,434 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), supporting a systems biology framework for decoding microbial habitat colonization. The award funds development of MagVAE, a transformer-based foundation model trained on biosphere-scale microbial genomic data to learn latent genomic representations predictive of microbial...
- The National Institute of Biomedical Imaging and Bioengineering awarded the Trustees of Boston University $245,250 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop living microbial sensors for continuous biochemical monitoring. The project will engineer and validate a self-renewing cell cartridge that maintains bacterial viability for multiple weeks using passive nutrient diffusion and...
- The National Center for Complementary and Integrative Health awarded Rutgers The State University of New Jersey, doing business as RBHS-School of Nursing, $592,063 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) for mechanistic research into probiotic interactions with host diet, digestive metabolism, and the microbial system. The award funds investigation of two metabolic pathways by which Lactobacillus rhamnosus GG regulates gut...
- The National Institutes of Health Office of the Director awarded The Leland Stanford Junior University $231,000 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to advance synthetic biology tools for engineering gut commensal bacteria as therapeutic agents. The project, titled "Advancing Synthetic Biology Tools for Engineering Gut Commensals" (R21EB037892), develops approaches to overcome current limitations in delivering engineered bacterial...
- The National Institute of Biomedical Imaging and Bioengineering awarded New York University School of Medicine $114,562 on June 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop and validate a novel diffusion MRI framework for prostate cancer imaging. The recipient will develop a fast, high-resolution, distortion-free diffusion-weighted imaging protocol for the prostate that overcomes limitations in current...
- The National Institute of Biomedical Imaging and Bioengineering awarded the University of Massachusetts $539,219 on June 9, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop polymeric lysosome-targeting chimeras (POLYTACS), a biomaterials platform for cell-specific degradation of membrane proteins. The award funds research to create a versatile POLYTACS platform enabling targeted protein degradation of...
- The National Institute of Biomedical Imaging and Bioengineering awarded New York University $186,504 on July 3, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop continuous flow manufacturing processes for antibody-loaded nanoparticles as a non-opioid therapy for oral cancer pain. The award funds development of the Biologics Sequential Nanoprecipitation (BIOSNAP) process, a novel manufacturing method designed...
The National Institute of Biomedical Imaging and Bioengineering, part of the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $132,300 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of programmable probiotic biofilms as a living therapeutic platform to address dysbiosis-driven chronic inflammatory diseases. Aim 1 chemically engineers probiotic biofilms using Streptococcus salivarius, functionalizing probiotic surfaces with NHS-activated, poly(ethylene glycol)-modified polymers to achieve stable mucosal colonization and inhibit pathogen adhesion. NHS groups form covalent bonds with amino residues on mucosal tissues, enhancing probiotic retention and creating a protective biofilm-like coating. As NHS functional groups hydrolyze, a poly(ethylene glycol)-based hydrophilic layer emerges to create a sterically repulsive anti-adhesive interface that limits pathogenic bacterial attachment and promotes probiotic niche dominance. The engineered biofilms will be systematically evaluated for physicochemical stability, biocompatibility, anti-adhesive activity, and epithelial interactions both in vitro and in vivo. Aim 2 addresses how engineered probiotic biofilms modulate microenvironment responsiveness. Performance occurs in New York, New York. The project period extends from September 1, 2026, through May 31, 2028. This is a K99/R00 Project Grant, a mentored research-to-independence award mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $132.3k | 8/27/26 |