Project Grant R21EB037892
- The National Institute of Allergy and Infectious Diseases awarded The Leland Stanford Junior University $434,090 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate the role of low-abundance bacterial species in gut microbiome colonization resistance against Clostridioides difficile infection. The project evaluates how low-abundance commensal species contribute to microbiome stability and pathogen resistance using synthetic microbial...
- The National Institutes of Health National Center for Complementary and Integrative Health awarded The Leland Stanford Junior University $787,346 on April 13, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to restore key functions to the industrialized gut microbiome. The project characterizes microbial strains capable of fermenting microbiota-accessible carbohydrates (MACs) into short-chain fatty acids (SCFAs)—acetate, propionate, and...
- The National Institute of Allergy and Infectious Diseases awarded The Leland Stanford Junior University $423,500 on April 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855, R21AI197001) to investigate how oxygen and bile acid processing shape the small intestinal microbiome and colonization resistance. The research addresses a critical knowledge gap: most microbiome studies rely on fecal samples that reflect the large intestine, not the functionally distinct...
- The National Institute of General Medical Sciences awarded The Leland Stanford Junior University $364,910 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to engineer enzyme-responsive elastin-like polypeptides that direct biomolecular phase behavior for applications in regenerative tissue engineering, controlled drug delivery, and scalable therapeutic biomolecule production. The recipient will develop stimuli-responsive biopolymers triggered by...
- The National Institutes of Health Office of the Director awarded The Leland Stanford Junior University $718,129 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, to engineer and optimize programmable synthetic G protein-coupled receptors (PAGERs) that enable precise, programmatic control of cellular behavior in response to specific molecular cues. The project addresses the limitations of current synthetic receptor technologies such as CAR-T therapies, which...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB), part of the Department of Health and Human Services National Institutes of Health, awarded $460,349 to The Leland Stanford Junior University on May 8, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for research on programmable therapeutic macromolecule delivery via engineered trogocytosis. The research develops TRANSFER (Trogocytosis-Based...
- The National Institute of Biomedical Imaging and Bioengineering awarded The Leland Stanford Junior University $192,500 for the development and testing of an ingestible robotic device capable of collecting visceral samples from the gastrointestinal tract on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of a programmable, swallowable robotic pill (RoboPill) designed to perform...
- The National Center for Complementary and Integrative Health, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $128,695 on July 20, 2026, under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The project investigates how gut-derived microbial metabolites regulate host energy metabolism, with focus on the mechanistic basis for cross-kingdom metabolic interactions relevant to...
- This five-year, $2.5 million Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research at Stanford University to systematically dissect complex synthetic gut bacterial communities. Principal Investigator Dr. Lance Palmer and collaborators at the University of California, Berkeley will develop an integrated model spanning molecular to community levels focusing on corrinoid metabolites. They will synthesize gut-relevant corrinoids and...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $421,456 on July 1, 2026, to discover and engineer biosynthetic pathways from plant natural products for therapeutic development under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research to characterize complete biosynthetic pathways of clinically approved plant-derived...
The National Institutes of Health Office of the Director awarded The Leland Stanford Junior University $231,000 on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to advance synthetic biology tools for engineering gut commensal bacteria as therapeutic agents. The project, titled "Advancing Synthetic Biology Tools for Engineering Gut Commensals" (R21EB037892), develops approaches to overcome current limitations in delivering engineered bacterial therapies, particularly in achieving stable colonization and the microbial densities required for therapeutic efficacy. The work focuses on the Bacteroides genus, the dominant bacterial genus in the human gut microbiome. Aim 1 seeks to expand therapeutic capabilities by developing a synthetic scaffolding system that enables engineered bacteria to secrete larger protein complexes—currently limited to approximately 80 kiloDaltons—capable of multivalent binding and more sophisticated biological functions. The project will create a protease-resistant scaffold to coordinate assembly and secretion of therapeutic proteins directly in the gut environment, with proof of concept demonstrated through treatment of Clostridium difficile infection in a mouse model using multimeric nanobodies. Aim 2 expands the scope of the platform but is not detailed in the source. Performance occurs in Palo Alto, California. The period of performance runs September 1, 2026, through August 31, 2028. This is a Project Grant, an assistance type under which NIH funds peer-reviewed research proposed by investigators at recipient institutions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $231.0k | 8/21/26 |