Project Grant R01EB037006
- Federal Grant Award Summary The University of Massachusetts received a $396,854 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. The award supports the development of a nanopore tweezer toolkit designed to analyze kinase structural dynamics and screen allosteric inhibitors. This research leverages protein nanopore sensor technology to...
- Federal Project Grant Award Summary The University of Massachusetts received a $406,250 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on August 15, 2025, with a completion date of July 31, 2030. The project, "Advancing Disease Modeling Through Mathematical Frameworks: Leveraging Single-Cell Spatial Data to Uncover Tissue-Specific Pathways and Immune Responses," develops...
- Federal Project Grant Award Summary The University of Massachusetts received a $431,656 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 1, 2025, through June 30, 2030. This award supports fundamental research to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop and apply novel methods to understand the...
- Federal Project Grant Award Summary The University of Massachusetts received a $401,490 Project Grant from the National Science Foundation (NSF) Division of Chemical, Bioengineering, Environmental, and Transport Systems under the Engineering program (CFDA 47.041), effective May 15, 2025 through April 30, 2028. The award supports the development of a modular toolset for imaging cellular metabolites using fluorogenic RNA riboswitches. This project will engineer genetically encodable, RNA-based...
- Federal Grant Award Summary The University of Massachusetts received a $797,584 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025, through April 30, 2030. The award funds fundamental research investigating how individual myosin molecular motors coordinate their activity within ensembles to drive complex cellular processes including muscle contraction and vesicular...
- Federal Project Grant Award Summary The University of Massachusetts Boston received a $422,173 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective July 1, 2025 through June 30, 2030. The award funds fundamental basic research investigating cellular signaling networks that control organism development and tissue patterning. The research employs the fruit fly Drosophila as a model...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2.64 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Massachusetts to develop antimicrobial polymer therapeutics for treating multidrug-resistant (MDR) wound biofilm infections. The award, effective April 1, 2026 through March 31, 2030, supports a collaborative research initiative integrating synthetic polymer...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $460,625 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 10, 2025, with completion targeted for July 31, 2030. The grant funds a research project titled "Decoding Cis-Regulatory Element Activity Through Deep Learning Frameworks," which seeks to advance understanding...
- Federal Project Grant Award Summary The University of Massachusetts Medical School received a $773,706 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded June 11, 2026, with a completion date of May 31, 2031. This award funds biomedical research investigating the regulation of programmed cell death through protein succination, a post-translational modification process mediated by...
- Federal Grant Award Summary The University of Massachusetts Medical School received a $1.675 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 1, 2026 through April 30, 2030. The award funds a four-year research project investigating the roles of truncated and mutated inverted terminal repeat (ITR) sequences in adeno-associated virus (AAV) vectors and their impact on...
The University of Massachusetts received a $539,219 Project Grant awarded on June 9, 2026, by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award supports the development of Polymeric Lysosome-Targeting Chimeras (PolyTACs), a biomaterials platform designed to enable targeted degradation of membrane proteins through polyvalent interactions. Unlike conventional occupancy-based drug approaches, this technology leverages lysosomal degradation pathways to achieve complete protein elimination, offering higher potency and potential resistance mitigation. The research extends protein degradation strategies to extracellular proteins, addressing a significant therapeutic gap, as this protein class comprises approximately one-fourth of the human proteome and is implicated in multiple human pathologies. The four-year project, extending through May 31, 2030, pursues complementary research strategies across three specific aims to demonstrate target-specific membrane protein degradation and establish biomedical applications of the PolyTACs platform. The work conducted at the University of Massachusetts in Hadley, MA, combines functionality-driven design approaches with cell and tissue-targeting capabilities, positioning the research to advance drug development methodologies within the biomedical engineering and pharmaceutical domains.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $539.2k | 6/9/26 |