Project Grant R01CA313939
- The National Institutes of Health National Cancer Institute awarded $689,865 to The Trustees of Columbia University in the City of New York on August 5, 2026, under the Cancer Biology Research program (CFDA 93.396) to develop methodological tools and frameworks for cancer microbiome study design and analysis. The award funds development of a comprehensive toolset to address contamination and batch-effect challenges in tumor microbiome research. Specific deliverables include a new method to...
- The National Cancer Institute awarded New York University $595,993 on July 16, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop integrated biologic technologies for selective inhibition of intracellular oncoproteins. The project aims to establish a platform technology that enables direct and selective manipulation of intracellular molecules, particularly driver oncoproteins and their interactions, with the long-term goal of addressing undruggable targets in cancer....
- The National Cancer Institute awarded the University of California, San Diego $671,226 on May 15, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop engineered native bacteria—host-derived E. coli strains—as a microbial platform for durable, targeted delivery of therapeutic molecules to the gut to prevent or treat colorectal cancer. The research addresses a critical gap in microbial therapies for colorectal cancer, which the American Cancer Society projects will account...
- The National Cancer Institute, a component of the Department of Health and Human Services, awarded The Trustees of Columbia University in the City of New York $702,132 on June 11, 2026, under the Cancer Treatment Research program (CFDA 93.395) to conduct multiplex single-cell chemical genomics screening aimed at identifying small molecule modulators of tumor cell-intrinsic immunogenicity in glioblastoma. The research program will expose glioblastoma neurosphere models to 3,792 small...
- The National Cancer Institute awarded The Trustees of Columbia University in the City of New York $681,818 on June 2, 2026, under the Cancer Treatment Research program (CFDA 93.395) to conduct research into restoring anti-tumor immunity in chromosomally unstable tumors. The research addresses chromosomal instability (CIN)—frequent chromosome missegregation during mitosis—as a genomic hallmark of solid tumors that correlates with immune evasion and resistance to immunotherapies. The project...
- The National Cancer Institute awarded Weill Medical College of Cornell University $716,183 on May 13, 2026, under the Cancer Treatment Research program (CFDA 93.395) to investigate and target co-inhibitory and co-stimulatory molecules in CAR T-cell therapies. The award funds research to overcome clinical barriers in adoptive cell therapies with chimeric antigen receptors, which show promise for cancer treatment but face challenges including insufficient T-cell persistence, antigen escape, and...
- The National Cancer Institute awarded New York University $723,777 on July 13, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop peptide-centric CAR T cell immunotherapies targeting the PRAME cancer-testis antigen across multiple tumor types and HLA allotypes. The research builds on the recipient's prior work with PC-CAR T cells to address fundamental barriers limiting immunotherapy reach: tumor antigen knowledge, HLA restriction, manufacturing complexity, and receptor...
- The National Cancer Institute, a component of the Department of Health and Human Services, awarded the Regents of the University of Michigan $669,278 on June 1, 2026, under the Cancer Treatment Research program (CFDA 93.395) to develop microbial-based cancer therapeutics engineered to deliver localized immune activation while minimizing systemic toxicity. The research focuses on nonpathogenic, tumor-tropic E. coli engineered to display membrane-anchored cytokines, specifically decoy-resistant...
- The National Cancer Institute, a division of the Department of Health and Human Services, awarded a cooperative agreement totaling $681,310 to The Trustees of Columbia University in the City of New York on June 24, 2026, under the Cancer Biology Research program (CFDA 93.396). The funded research investigates mechanisms that promote bone metastasis in prostate cancer, the major cause of death in metastatic prostate cancer patients. Columbia will use genetically-engineered mouse models (GEMMs) to...
- The National Cancer Institute, under the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $630,089 on May 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393). The award funds research to characterize the molecular mechanisms by which the DNA translocase SMARCAL1 suppresses anti-tumor immune responses and to identify other DNA damage response factors that function analogously to...
The National Cancer Institute, part of the Department of Health and Human Services, awarded The Trustees of Columbia University in the City of New York $635,722 on July 23, 2026, under the Cancer Treatment Research program (CFDA 93.395) to advance probiotic-guided CAR-T cell therapy toward clinical application. The project, titled "Advancing ProCAR Therapy Toward Clinical Application," addresses limitations in current engineered cell therapies for treating solid tumors. Specifically, the work improves pharmacokinetics of engineered probiotics through genetic attenuations and gene circuits, and enables long-range ProCAR-T cell interactions through probiotic-payload production and ProCAR-T cell engineering. The approach harnesses synthetic biology to design cooperative interactions between mammalian effectors and engineered probiotics, allowing probiotic-guided T cells to overcome challenges including absent or variable antigen expression, antigen loss as a resistance mechanism, and poor tumor infiltration. Performance occurs at Columbia University's New York, New York campus. The period of performance extends through June 30, 2031. The award is structured as a Project Grant, the standard assistance type for investigator-initiated research under the National Cancer Institute's Cancer Treatment Research program, which supports discovery, development, and clinical testing of improved cancer treatment methods across all therapeutic modalities including biological therapy and molecularly targeted approaches.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $635.7k | 7/23/26 |