Project Grant DP2AI207712
- The National Institute of Biomedical Imaging and Bioengineering, part of the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $132,300 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of programmable probiotic biofilms as a living therapeutic platform to address dysbiosis-driven chronic...
- The National Cancer Institute, part of the Department of Health and Human Services, awarded The Trustees of Columbia University in the City of New York $635,722 on July 23, 2026, under the Cancer Treatment Research program (CFDA 93.395) to advance probiotic-guided CAR-T cell therapy toward clinical application. The project, titled "Advancing ProCAR Therapy Toward Clinical Application," addresses limitations in current engineered cell therapies for treating solid tumors. Specifically,...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $3,144,408 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate regulatory T cell memory in human tissues. The award funds research to characterize the role, identity, and function of human regulatory T cells (Tregs) across diverse tissues and their interactions with immune and structural cells. The project will...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $821,367 on May 1, 2026, to support systematic functional variant-to-pathway and phenotype evaluation in genetic disorders of the immune system. The recipient will conduct functional variant mapping of rare and common genetic variants in immune system diseases using a CRISPR-base editing framework in primary human T cells. The work focuses on clarifying variants of...
- The National Institute of Allergy and Infectious Diseases awarded New York University a Project Grant of $791,797 on February 4, 2026, to investigate intestinal programming of gut-associated germinal centers under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research examines how the intestinal microbiota directs differential programming of local B cell responses toward production of regulatory immunoglobulin A (IgA) in gut-associated germinal centers. IgA, produced by...
- The National Institute of Allergy and Infectious Diseases awarded New York University $827,768 on August 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate how microbial exposure influences the persistence of long-lived plasma cells in the small intestinal lamina propria. The research will employ imaging and single-cell profiling to define how microbial exposures shape the generation, turnover, and function of long-lived plasma cells by comparing...
- The National Institute of Allergy and Infectious Diseases awarded $836,711 to The Trustees of Columbia University in the City of New York on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate whether selective matching of donor and recipient major histocompatibility complex class II molecules decreases rejection and promotes regulatory tolerance in intestinal transplantation. The research addresses high rejection rates in intestinal...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $107,434 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), supporting a systems biology framework for decoding microbial habitat colonization. The award funds development of MagVAE, a transformer-based foundation model trained on biosphere-scale microbial genomic data to learn latent genomic representations predictive of microbial...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $822,280 on August 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on intragraft alloreactive T cells in human solid organ transplantation, with the goal of controlling rejection after transplantation. The research dissects intragraft T cell alloimmunity using longitudinal surveillance biopsies from intestinal...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $194,397 on July 3, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to support a K23 research career development award for Dr. Yael Nobel. The award funds development of microbiome-based predictive models to improve outcomes in liver transplant recipients. Dr. Nobel, a board-certified transplant hepatologist and early-career researcher, will...
The Department of Health and Human Services National Institutes of Health Office of the Director awarded $754,366 to The Trustees of Columbia University in the City of New York on September 1, 2026, under the Trans-NIH Research Support program (CFDA 93.310) to investigate the immunotherapeutic potential of probiotic extracellular vesicles as a therapeutic platform for immune dysregulation diseases. The research will elucidate molecular and cellular mechanisms by which probiotic extracellular vesicle hydrogels regulate immune and tissue responses, and evaluate their potential as platforms for regenerative and tolerogenic therapies. Project 1 will map how extracellular vesicle proteomic features correlate with functional and transcriptional states in human primary cell models of tissue repair and immune regulation. Project 2 will define immune mechanisms underlying probiotic extracellular vesicle-driven vascularization and test their capacity to induce antigen-specific tolerance in preclinical autoimmune disease models. The work targets immune dysregulation as a driver of chronic wounds, autoimmune disorders, and other conditions affecting tens of millions of people in the United States. The award is a project grant with a period of performance from September 1, 2026, through August 31, 2031. Work is performed in New York, New York. Columbia University's Sponsored Projects Administration Division administers the award.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $754.4k | 8/28/26 |