Project Grant K99GM166865
- Federal Project Grant Award Summary The Trustees of Columbia University in the City of New York, Health Sciences Division, received a $2,056,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 1, 2025, through August 31, 2029. This four-year award funds the development of novel computational tools and methodologies for early detection and inference of emerging...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $215,668 on July 8, 2026, to support an Advanced Graduate Training Program in Molecular Biophysics and Structural Biology under the Biomedical Research and Research Training assistance listing (CFDA 93.859). The training program prepares PhD students for careers integrating biology, chemistry, physics, computation, and medicine through theoretical, computational, and...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $444,907 on May 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on systems-level principles and mechanisms underlying cellular adaptation. The funded work investigates how cells achieve adaptive gene-expression states during short-term physiological adaptation and long-term adaptive evolution, with three primary research...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $125,000 on May 13, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop an integrated computational and experimental platform for decoding, modulating, and designing protein free energy landscapes. The funded research will establish methods for resolving complete protein free energy landscapes and predicting how they respond to...
- The National Institute of General Medical Sciences awarded Trustees of Boston University $449,625 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for discovering temporal changes in host-microbiome interactions. The award funds development of a deep learning framework led by principal investigator Dr. Chao Zhang. The project will deliver two primary outputs over five years: a microorganism identification pipeline using...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded New York University $421,737 on March 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop data-driven, predictive biophysical models of molecular mechanisms underlying cellular quiescence in microorganisms. The research focuses on quantitative relations between physiological traits and molecular processes in...
- The National Institute of Biomedical Imaging and Bioengineering, part of the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $132,300 on September 1, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The award funds development of programmable probiotic biofilms as a living therapeutic platform to address dysbiosis-driven chronic...
- The National Institute of General Medical Sciences (NIGMS) of the Department of Health and Human Services awarded The Trustees of Columbia University in the City of New York $227,652 on June 26, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to model the cascade of genome rearrangements in the ciliate Oxytricha trifallax. The recipient will develop quantitative summaries of rearrangement progression using unsupervised learning to uncover how sequence complexity...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $125,000 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type Project Grant K99GM159103). The award funds research into the molecular causes and physiological and behavioral consequences of extreme glucocorticoid levels in Peromyscus mice species. The investigator will identify biochemical causes and physiological...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $446,876 on February 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the dynamic interplay between genome organization and long noncoding RNAs in the regulation of gene expression. The research uses single-cell live imaging approaches in Drosophila embryos to measure transcriptional dynamics and examine how long-range...
The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $107,434 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), supporting a systems biology framework for decoding microbial habitat colonization. The award funds development of MagVAE, a transformer-based foundation model trained on biosphere-scale microbial genomic data to learn latent genomic representations predictive of microbial colonization potential across diverse environments, and mechanistic investigation of YigZ, a conserved translational regulator essential for E. coli gut colonization, using ribosome profiling, quantitative proteomics, and genetic perturbation. The research establishes a scalable framework for linking microbial genotypes to ecological and physiological phenotypes. The mentored K99 phase supports career development of the principal investigator in deep learning, functional genomics, and translational control, with protected time for strengthening mentorship, communication, and leadership skills in preparation for transition to a faculty position. Research and training are conducted in the laboratory of Dr. Saeed Tavazoie at Columbia University in New York, New York. The period of performance runs from September 1, 2026, through August 30, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $107.4k | 7/24/26 |