This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $594,956 to the University of South Florida to conduct research on the mechanisms underlying stretch-evoked activation of esophageal vagal afferents. The goal is to determine the mechanosensitive channels and sodium channels responsible for transducing esophageal stretch into vagal afferent...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $136,449 project grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Regents of the University of California, Berkeley. The award, which runs from December 1, 2024 to November 30, 2026, will fund research to optimize the use of CRISPR-mediated gene downregulation to rapidly test whether genes linked to human obesity are required for the function of...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $245,123 to support research on the role of vascular sympathetic neurons in brown adipose tissue and their impact on systemic metabolism. The project, led by The Trustees of Columbia University in the City of New York, aims to use novel genetic and chemogenetic tools, advanced...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $546,503.00 to Duke University to conduct research on how the gut senses and communicates bitter stimuli to the brain. The research aims to determine how specialized gut cells called neuropod cells detect bitter compounds through taste receptors and signal this information to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, supports research to understand the neural populations in the nucleus of the solitary tract (NTS) that mediate the suppression of food intake. The $502,233 award to the Regents of the University of Michigan aims to define the NTS neuron populations that control food intake and body weight, and distinguish...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Duke University a $241,500 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to study the regulation of metabolic diseases by the human commensal bacterium Clostridium immunis. The overarching goal is to determine the mechanism by which an exopolysaccharide (EPS) secreted by C. immunis decreases visceral adiposity, a key risk factor for type 2 diabetes and...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $516,648 to The Leland Stanford Junior University to conduct research on understanding the mechanisms by which microbially derived metabolites regulate host gut inflammation. The award period runs from August 28, 2024 to February 28, 2027. The research aims to determine the regulatory...
This federal Project Grant award of $726,140.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the neural circuits and cellular mechanisms underlying visceral pain processing in the spinal cord and brainstem, with the goal of advancing understanding and treatment of visceral pain conditions such as irritable bowel syndrome,...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $747,500.00 to support research on memory formation in the enteric nervous system (ENS). The project aims to build the tools required for studying the formation and meaning of ENS memories, and then use these tools in combination with various perturbations to transform the...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,600,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Icahn School of Medicine at Mount Sinai. The project, titled "Decoding Endocrine and Paracrine Communication Through Mammokines," aims to discover new signaling molecules from the mammary gland that influence metabolic function and the progression of obesity and type 2...