Evaluating the role of human obesity genes in specific neuronal populations in vivo by crispri
Ended Project Grant Awarded Last action
- Award ID
- F31DK137538
- Recipient
-
The Regents Of The University Of California UEI GS3YEVSS12N6
- Awarding agency
-
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $199,779
Award facts
- Assistance listing
- 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research
- Completion date
- Place of performance
- Berkeley, CA 94710, USA
Award details come from USAspending.gov.
Description
- Abstract
- Obesity leads to an increased risk for type 2 diabetes, heart attack, hypertension, stroke, and many types of cancer-conditions which are among the leading causes of death in the US. Through twin and family studies, obesity has been found to have a 40-70% heritability rate, pointing to a strong genetic etiology. The long-term objective of our studies is to determine how genetic variation predisposes humans to obesity and the accompanying therapeutic implications. Here we are optimizing the development of a state-of-the-art approach based on crispr-mediated gene downregulation in a temporally, anatomically and cell-type specific manner, to rapidly test whether genes in which variation predisposes to obesity are required for the function of specialized neurons in the mouse hypothalamus. We will also be using this approach to test the hypothesis that genes in which mutations cause obesity by affecting the function of the primary cilia, a cell surface projection that receives and transduces select intercellular signals, are required for the function of neurons of central leptin-melanocortin system in mice.
Transactions
| Action | Obligated | Date |
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| Amendment | -$28,764 | |
| Amendment | $46,047 | |
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| Amendment | $45,483 | |
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| Original award | $45,483 |
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Quick answers
Who received award F31DK137538?
F31DK137538 was awarded to The Regents Of The University Of California by National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health) on December 1, 2024.
How much is award F31DK137538 worth?
$199,779 has been obligated on F31DK137538.
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