Project Grant K99DE034722
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a Project Grant of $690,195 under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct fundamental research on neuroimmunology and reparative dentinogenesis. The award, effective March 1, 2026 through February 28, 2031, supports investigation into how neuronal-derived calcitonin gene-related peptide (CGRP) regulates immune and mineralizing cell...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a Project Grant of $469,207 on February 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct research on pharmacological inhibition of ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) to promote cementum regeneration and restore periodontal function. The research addresses a critical gap in therapeutic approaches for...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a $1.397 million Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) on August 11, 2025, to conduct a multistage mixed-methods research study examining the impact of state Medicaid reimbursement policies for Silver Diamine Fluoride (SDF) treatment on pediatric oral health outcomes and provider adoption patterns. The five-year study,...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a Project Grant in the amount of $568,759 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award, effective May 1, 2026, through April 30, 2031, funds research investigating pathogen synergy and immune subversion mechanisms in periodontal disease. The project delivers scientific research...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a $645,988 Project Grant on August 13, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to conduct a two-year investigation into bacteriophages' roles in dental caries and the oral microbiome. The research team will characterize the composition, abundance, and functional significance of oral phages in early childhood caries (ECC) by...
- Federal Grant Award Summary Award Details: The National Institute of Dental and Craniofacial Research (NIDCR) awarded Augusta University Research Institute, Inc. a Project Grant totaling $645,009 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award period runs from June 15, 2025, through June 14, 2027. Research Scope: This grant funds a research project investigating the molecular mechanisms of alveolar bone loss in periodontitis through examination of...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Pennsylvania a Project Grant totaling $522,405 under the Oral Diseases and Disorders Research program (CFDA 93.121) effective May 1, 2026, through April 30, 2031. This research project investigates the role of taste receptor cells in periodontal homeostasis and disease prevention. The study focuses on understanding how solitary chemosensory cells (SCCs) and macrophages in...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a $393,750 Project Grant on May 15, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the mechanisms linking psychological stress to bone loss and impaired skeletal growth. The research employs a rodent model of repeated social defeat (RSD) to examine the relationship between immunological processes, mental health, and...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Toledo a Project Grant of $947,264 under the Oral Diseases and Disorders Research program (CFDA 93.121), effective May 1, 2025, through April 30, 2028. This three-year research initiative investigates IL-17 (Interleukin-17) receptor signaling in megakaryocytes and its role in oral mucosal immune responses during oropharyngeal candidiasis (OPC) caused by Candida albicans. The...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Pittsburgh a Project Grant totaling $454,002 (awarded September 15, 2025; completion date September 14, 2027) under the Oral Diseases and Disorders Research program (CFDA 93.121). This research grant supports basic and translational scientific investigation into the dichotomous effects of phosphate (inorganic phosphate) on periodontal health and disease. The study...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded The Ohio State University a Project Grant totaling $116,937 under the Oral Diseases and Disorders Research program (CFDA 93.121) on May 15, 2026, with a completion date of May 14, 2028. This research project investigates the effects of altered immunity in X-linked hypophosphatemia (XLH) on dental and periodontal infection outcomes. The research addresses a critical gap in understanding how immune dysregulation—characterized by elevated inflammatory states in XLH patients—contributes to high prevalence rates of pulp necrosis, dental abscesses, and periodontitis across all age groups in this patient population. The project delivers comprehensive research services examining immune cell functionality and cytokine profiling in XLH patients undergoing conventional therapy (oral phosphorus and vitamin D supplementation) versus treatment with FGF23 antibody (burosumab). Research outputs will include mechanistic data on how altered immunity in monocytes, neutrophils, T-cells, and B-cells influences dental and periodontal disease manifestations, and comparative evaluation of treatment effects on immune response pathways. This investigation directly supports NIDCR's mission to advance fundamental knowledge about oral and craniofacial health and translate findings into improved prevention and treatment strategies for populations with genetic mineral metabolism disorders.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $116.9k | 5/13/26 |