Project Grant R56DE034689
- This $597,807 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will establish a novel 13C-labeled metabolite library for the study of dental caries. The key objectives are to: Create a 13C-labeled oral bacterial metabolite reference library for Streptococcus mutans and Streptococcus gordonii using SWATH LC-MS, with dual peaks identified and curated to improve rigor...
- This federal Project Grant award of $163,411 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports research to characterize the nutritional niches and interactions between Streptococcus mutans, a primary driver of dental caries, and other commensal oral streptococci species. The research aims to understand how these microcolony biofilm structures form, the interactions between S....
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $422,665 Project Grant to Oregon State University (OSU) to develop an integrated dental plaque bioanalytical platform for point-of-care diagnostics of oral diseases. The project aims to detect and quantify hydrogen peroxide and lactate produced by beneficial and pathogenic oral bacteria, and establish a correlation between oral caries...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $198,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Pennsylvania State University (Penn State) to conduct research on integrating population-wide oral microbiome data to better understand health differences in the United States. The project, which will run from July 1, 2025 to June 30, 2027, aims to disentangle how an individual's background and socioeconomic factors...
- Vulcan Biologics Inc. received a $267,556 National Institutes of Health National Institute of Dental and Craniofacial Research project grant under the Oral Diseases and Disorders Research program to develop a novel approach combining bacteriophage-mediated decolonization with microbial engraftment to modulate the supragingival microbiome for enhanced anti-cariogenic therapy. The grant period spans from January 15, 2021 to September 15, 2021. The research aims to foster sustained modulation of...
- The Project Grant award of $205,000.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the relationship between the oral microbiome and adverse outcomes in pediatric hematopoietic cell transplant recipients. The key products and services to be delivered under this award include: Collecting oral samples (supragingival plaque and saliva) and blood samples...
- This federal Project Grant award of $310,500.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to Virginia Commonwealth University. The funding supports a comparative experimental evolution study of gene essentiality in the oral bacteria Streptococcus sanguinis and S. mutans. The project aims to investigate the similarities and differences in essential genes between these two species, which...
- This $499,996 federal Project Grant award from the National Science Foundation's Biological Sciences Program (CFDA 47.074) will fund a research project conducted by The Pennsylvania State University to reconstruct the history of the human oral microbiome on a global scale. The project aims to understand the evolutionary mechanisms that drive changes in human microbiome diversity over time, particularly in response to shifts in geography, environment, and culture. By analyzing bacteria...
- This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $673,091 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to the University of Pittsburgh. The grant, which runs from August 14, 2025 to May 31, 2028, aims to advance the genomics knowledge base for oral diseases, focusing on dental caries and periodontitis. Key activities include performing the largest genome-wide association scans of these conditions, developing...
This Project Grant award, valued at $645,988.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The primary objective is to leverage an eco-systems biology approach and phage-specific computational platform to define the role of bacteriophages in the development of dental caries and the broader oral microbiome. Key activities include collecting caries-free and caries-active plaque samples, performing DNA/RNA sequencing of total and/or virulent phage populations, and utilizing the IVIRUS 2.0 toolkit for sequencing analysis. This research aims to describe key phage taxa and accessory genes that contribute to shifts in bacterial population structures during the transition from oral health to disease. The award was granted to The Ohio State University and has a performance period from August 13, 2025 to August 12, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $646.0k | 8/13/25 |