Federal Grant Award Summary

The National Institute of Dental and Craniofacial Research (NIDCR) awarded the University of Pennsylvania a Project Grant totaling $522,405 under the Oral Diseases and Disorders Research program (CFDA 93.121) effective May 1, 2026, through April 30, 2031. This research project investigates the role of taste receptor cells in periodontal homeostasis and disease prevention. The study focuses on understanding how solitary chemosensory cells (SCCs) and macrophages in gingival tissue express bitter taste receptors and respond to bacterial stimuli to initiate protective innate immune responses. The primary deliverables include research findings on taste signaling mechanisms in gingival macrophages and identification of protective mechanisms by which these chemosensory cells reduce periodontal bone loss in response to bitter compound stimulation.

This basic research award addresses a significant public health challenge, as periodontal disease affects approximately 50% of U.S. adults over age 30, with approximately 9% experiencing severe periodontitis. The research is designed to advance fundamental knowledge of oral health and disease mechanisms, with potential applications toward developing prevention and treatment strategies for periodontal conditions and associated systemic health complications. The work will be performed at the University of Pennsylvania's Philadelphia, PA facility.