This $656,315 Project Grant was awarded on September 1, 2024 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The overarching goal is to mechanistically study the effect of biomaterial cyclic strain on the pathogenesis of oral microbes, including the fungal strain Candida albicans and denture-related microbiota. The research aims to understand how chewing actions may fuel the progression of...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical University of South Carolina. The goal of this 2-year research project is to define how oral pathogens affect aging-associated immune responses and determine if inhibition of the CD38 enzyme can alleviate inflammatory bone loss and aging-associated immune responses induced by oral bacteria. The researchers will...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $109,548 Project Grant under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) to the Regents of the University of Michigan. The grant supports a research project focused on investigating the role of myeloid cells in the evolution of precancerous oral lesions to head and neck squamous cell carcinoma (HNSCC). The project aims to develop a preclinical mouse model to study the transition from...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), supports comprehensive research to understand the interaction between Candida albicans and Streptococcus mutans and how it drives the formation and virulence of cariogenic biofilms. The $460,885 award, spanning March 2025 to February 2030, aims to investigate the transcription factors and protein kinase networks in...
This $390,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under its Oral Diseases and Disorders Research program (CFDA 93.121), supports research to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The key products and services to be delivered include: Optimizing a high-throughput, single-cell co-culture system to isolate individual tumor-killing T...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a 5-year, $628,965 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the Icahn School of Medicine at Mount Sinai to study how immune cells, specifically macrophages, regulate the development and differentiation of salivary gland cells. The research aims to elucidate the cellular and molecular mechanisms by which macrophages govern salivary gland progenitor dynamics and epithelial cell patterning,...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,159,930 to investigate the role of salivary zinc in modifying the activity of the antimicrobial protein histatin 5 towards the opportunistic fungus Candida albicans. The research aims to determine how zinc binding to histatin 5 alters the fungal cell wall composition, adhesion, and invasion of oral epithelial...
This $234,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), supports research to determine the functional roles and mechanisms of the human microbiome in oral squamous cell carcinoma (OSCC) pathogenesis. The University of Colorado-Denver, through this grant, will 1) define OSCC-associated metagenomic and metabolomic signatures in treatment-naive OSCC cases and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $205,000.00 to The Regents of the University of California, San Francisco (UCSF) to investigate the relationship between the oral microbiome and adverse outcomes in pediatric hematopoietic cell transplant recipients. The research aims to determine how dental caries and the cariogenic oral microbiome prior to...
This $162,216 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) supports the ADA Forsyth Institute's research to investigate microbe-microbe interactions within the oral microbiome. The study aims to employ a combination of expansion microscopy and multiplex FISH imaging to analyze microbial organization and quantify adhesion forces at the single-cell level. This approach...