Project Grant R56DE033406
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, will fund research at the University of Pittsburgh to investigate the role of the TRPS1 transcription factor in regulating the formation and mineralization of dental tissues. The $593,468 award, spanning September 2024 to September 2026, aims to (1) determine how TRPS1 regulates communication between developing...
- This $762,432 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), part of the U.S. Department of Health and Human Services, under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant was awarded to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), a non-profit research organization, to investigate the role of the CD73 enzyme in controlling inflammation and bone loss associated with...
- This Project Grant award, totaling $645,009.00 and provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), aims to investigate the role of osteocytes and the nucleotide-binding oligomerization domain containing 1 (NOD1) receptor in the mechanism of alveolar bone loss associated with periodontal disease. The research, to be conducted by Augusta University Research Institute, Inc. (doing...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $673,091 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to the University of Pittsburgh. The grant, which runs from August 14, 2025 to May 31, 2028, aims to advance the genomics knowledge base for oral diseases, focusing on dental caries and periodontitis. Key activities include performing the largest genome-wide association scans of these conditions, developing...
- This $385,116 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research on senescent periodontal ligament cells as a potential therapeutic target for age-associated periodontitis. The award to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) aims to investigate the mechanisms by which aging increases periodontal disease bone loss,...
- The federal Project Grant award of $309,038, issued on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports the development of a novel anti-infective therapy for treating periodontitis. The project aims to develop a first-in-class inhibitor of the "red complex" bacteria (P. gingivalis, T. forsythia, and T. denticola) that are considered the causative agents of periodontitis, a...
- This federal Project Grant award of $311,000.00 from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will be used by the University of Washington to conduct research to characterize the microbial and inflammatory state within distant clinically healthy tissues in patients with active periodontal disease. The research aims to increase understanding of how inflammation is triggered and maintained during the...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $582,000 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Rochester. The grant, awarded on May 1, 2025, will support research aimed at understanding the mechanisms underlying peri-implantitis, an inflammatory condition affecting dental implants. The research will utilize a rat model of peri-implantitis to investigate the role of epigenetic factors, such as the...
- This $442,750 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a research project titled "A Pathomimetic Gingiva-on-a-Chip for Assessing Microbiota-Directed Anti-Inflammatory Therapeutics" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The project aims to identify metabolites that can selectively enhance beneficial oral...
- This federal Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is funding research to develop a bio-inspired scaffold (PerióPatch) for regenerating Sharpey's fibers and the periodontal ligament (PDL). The research aims to integrate biophysical and biochemical cues into a matrix to guide PDL stem cell migration, growth, and the formation of well-aligned PDL principal and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $454,002 to the University of Pittsburgh to conduct research on the interplay between dietary phosphate availability, its pro-osteogenic and pro-inflammatory effects, and the TRPS1-regulated formation and homeostasis of the periodontium. The research aims to determine how dietary phosphate levels impact the health and disease of the tissues that anchor the tooth to the jawbone, with a focus on the roles of the TRPS1 transcription factor in regulating gene expression and tissue formation. The project will run from September 15, 2025 to September 14, 2027, and the findings could lead to improved prevention and treatment strategies for periodontal disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $454.0k | 9/15/25 |