Project Grant K99AG101696
- Federal Grant Award Summary Cornell University received a $458,871 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 1, 2026 through January 31, 2028 to conduct research on epigenetic aging in mice maintained in semi-natural field environments. The research employs an innovative "rewilding" paradigm that bridges biomedical and ecological approaches by studying laboratory mice in large outdoor enclosures rather than traditional...
- Federal Project Grant Award Summary Cornell University received a $2.21 million Project Grant from the National Institute on Aging (CFDA 93.866, Aging Research program) awarded on August 15, 2025, with completion targeted for July 31, 2029. The award supports a four-year research initiative titled "System-Wide and Mechanistic Deconvolution of Autophagy in Cellular Aging," conducted at Cornell's Ithaca, New York campus. The research deliverables include the systematic dissection and...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $109,076 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded March 3, 2026, with completion scheduled for September 2, 2029. The award supports research investigating vulnerable cell populations in aging-induced circadian clock remodeling and disruption through advanced genomic analysis techniques. The research deliverables center on high-throughput...
- Federal Grant Award Summary This $255,190 Project Grant award, announced March 17, 2026, and funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research investigating lysosome homeostasis mechanisms and their role in aging-related diseases. The research, conducted at Weill Medical College of Cornell University in New York, focuses on understanding how cells sense and respond to lysosomal stress through autophagy protein modifications and how...
- Federal Project Grant Award Summary Cornell University's Office of Sponsored Programs received a $440,900 project grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on May 1, 2026, with a completion date of April 30, 2028. The grant funds research investigating the impact of vitamin B12 (B12) status on mitochondrial disease onset and progression. The research addresses the hypothesis that B12 deficiency acts as a secondary pathogenic factor that further...
- Federal Grant Award Summary The Buck Institute for Research on Aging received a $809,486 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion scheduled for January 31, 2031. This award supports biomedical research investigating the role of oxidation resistance 1 (OXR1) and retromer proteins in brain aging and Alzheimer's Disease and Related Dementias (ADRD). The research deliverables include...
- Federal Project Grant Award Summary Vanderbilt University's Sponsored Programs Administration received a $435,875 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded May 15, 2026, with completion targeted for April 30, 2028. The award funds research to define the characteristics of a resilient organelle interactome during aging. The research will generate detailed three-dimensional maps of organelle interactions in aging animals using advanced...
- Federal Project Grant Award Summary Columbia University's Health Sciences Division received a $3.44M Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025 through August 31, 2029. This research initiative investigates the molecular mechanisms and genetic basis of human ovarian aging, addressing a significant gap in women's health research. The project employs advanced genomic sequencing techniques, including...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Weill Medical College of Cornell University a Project Grant totaling $466,125.00 on August 1, 2025, under the Aging Research program (CFDA 93.866) to support a two-year research initiative examining aging in the liver, alcohol consumption, and the retinoic acid pathway. The research will be conducted at the institution's New York facility through July 31, 2027. The project investigates how retinoic acid receptor...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a Project Grant of $852,273 under the Aging Research program (CFDA 93.866), effective September 1, 2025, with completion targeted for May 31, 2030. This project delivers comprehensive research services focused on genetic mapping of N6-methyladenosine (M6A) and pseudouridine (Ps) RNA modifications in the aging human brain and their relationship to Alzheimer's disease...
Cornell University's Office of Sponsored Programs received a $136,350 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded June 1, 2026, with completion by May 31, 2028. This award supports a K99/R00 career development initiative investigating how environmental complexity modulates behavioral and molecular aging trajectories in genetically identical C57BL/6J mice. The research utilizes a naturalistic outdoor enclosure system to examine aging across multiple biological levels—including behavior, cognition, gene expression, DNA methylation, mitochondrial function, and gut microbiome composition—addressing a critical gap in aging research by moving beyond simplified laboratory conditions to ecologically valid experimental environments. The project deliverables encompass comprehensive characterization of aging-related phenotypes under naturalistic versus controlled conditions, transcriptomic and epigenetic profiling across treatment groups, and efficacy testing of rapamycin as a pro-longevity intervention in semi-natural environments. By merging evolutionary and biomedical perspectives, this research will identify which aging biomarkers and interventions remain robust across environmental contexts versus those that are environmentally contingent, generating evidence to improve the translational validity of preclinical aging models and inform future therapeutic development for age-related diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $136.4k | 5/26/26 |