Project Grant R21AG100723
- Federal Project Grant Award Summary Cornell University received a $2.21 million Project Grant from the National Institute on Aging (CFDA 93.866, Aging Research program) awarded on August 15, 2025, with completion targeted for July 31, 2029. The award supports a four-year research initiative titled "System-Wide and Mechanistic Deconvolution of Autophagy in Cellular Aging," conducted at Cornell's Ithaca, New York campus. The research deliverables include the systematic dissection and...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $740,075 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with completion targeted for June 30, 2030. The grant supports research investigating the role of Complex III-derived reactive oxygen species (CIII-ROS) in mitochondrial-nuclear crosstalk as a mechanism underlying Alzheimer's disease and related dementias. The research...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Columbia University's Health Sciences Division a $690,865 Project Grant effective January 15, 2026, through December 31, 2030, under the Aging Research program (CFDA 93.866). The research project delivers scientific investigation into the mitochondrial and energetic foundations of resilience in human aging, addressing a critical gap in geroscience by linking altered mitochondrial biology—specifically diminished...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $255,190 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded March 17, 2026, with completion scheduled for September 21, 2027. The award supports biomedical research directed toward understanding lysosomal homeostasis and its dysfunction in aging-related diseases. The research investigates how cells sense lysosomal stress and coordinate the...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $711,898 project grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective September 30, 2025, with a completion date of June 30, 2030. This award supports biomedical research aimed at understanding the mechanisms by which apolipoprotein E4 (a major genetic risk factor for Alzheimer's disease) contributes to tau-induced neurodegeneration through microglial...
- Federal Grant Award Summary The Broad Institute of MIT and Harvard received a $610,836 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective September 1, 2025, through May 31, 2030. This award supports research on the genetic dissection of mitochondrial-nuclear (mitonuclear) interactions in aging and neurodegenerative disease, with particular focus on Alzheimer's disease and related dementias (ADRD). The research leverages two key...
- Federal Grant Award Summary Weill Medical College of Cornell University received a $216,113 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective June 1, 2025, through May 31, 2027. The research project investigates therapeutic targeting of GDF15-GFRAL (growth differentiation factor 15-GFRAL receptor) signaling to treat mitochondrial myopathy, a...
- Federal Project Grant Award Summary Cornell University received a $458,871 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with completion targeted for January 31, 2028. The project investigates epigenetic aging patterns in mice maintained in semi-naturalistic outdoor enclosures ("rewilded" lab mice) to bridge biomedical research approaches with ecological complexity. The research examines how physical and social...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Weill Medical College of Cornell University a Project Grant of $212,770.00 (awarded August 15, 2025, with completion by April 30, 2030) under the Aging Research program (CFDA 93.866) to advance research and mentoring initiatives addressing elder mistreatment among persons living with Alzheimer's disease and related dementias (ADRD). The grant supports two primary objectives: mentoring and supporting the next...
- Federal Grant Award Summary Weill Medical College of Cornell University received a $268,650 project grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with completion targeted for May 31, 2027. This research initiative investigates a novel bone-brain axis mechanism in Alzheimer's disease (AD) by examining the role of calvarial skeletal stem cells (SSCs) in regulating immune cell infiltration to the central nervous system. The...
Cornell University received a $440,900 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective May 1, 2026 through April 30, 2028. The award supports research investigating the impact of vitamin B12 status on mitochondrial disease onset and progression. The project addresses a significant gap in understanding how B12 deficiency, which is prevalent in older adults, vegetarians, and individuals taking certain pharmaceuticals, exacerbates mitochondrial DNA (mtDNA) damage and impairs energy production in patients with mitochondrial DNA depletion syndromes—rare inborn errors of metabolism characterized by severe multi-organ dysfunction. The research will define molecular mechanisms whereby B12 deficiency affects mtDNA stability and determine whether B12 deficiency acts as a "second hit" contributing to the clinical heterogeneity observed in mitochondrial disease presentations. The project will generate foundational scientific knowledge regarding the relationship between B12 metabolism and mitochondrial function, with potential implications for identifying preventive interventions and therapeutic targets in mitochondrial disease management. Through basic and translational research conducted at Cornell University's facilities in Ithaca, New York, the award will contribute to the National Institute on Aging's mission to support biomedical research directed toward understanding age-related diseases and conditions affecting older populations.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $440.9k | 5/1/26 |