Project Grant K99AG093069
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $478,624 to President and Fellows of Harvard College, operating as Harvard Medical School, on August 15, 2025, through the Aging Research program (CFDA 93.866) to develop cross-platform fluorescent reporters for measuring 26S proteasome and VCP/P97 complex activities. The project, concluding July 31, 2027, addresses a critical gap in aging and neurodegenerative disease research by creating molecular tools to...
- The National Institute on Aging awarded Harvard Pilgrim Health Care, Inc. $706,310 on May 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a longitudinal study examining the interplay among reproductive, molecular, and chronological age in relation to aging-related conditions in women. The study leverages existing high-quality data and biosamples from a well-phenotyped population of over 850 women followed from recruitment in early pregnancy in 1999–2002 for over two decades....
- The National Institute on Aging awarded $660,000 to The General Hospital Corporation (doing business as Massachusetts General Hospital) on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop machine learning models for single-cell aging clocks that track aging trajectories across multiple organs and species. The recipient will integrate large-scale, publicly available single-cell transcriptomics datasets from mouse, rat, human, and invertebrate aging models totaling...
- The National Institute on Aging awarded Massachusetts Institute of Technology $723,962 on June 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a systems-level analysis of DNA damage and repair in senescence, aging, and cancer. The research applies mass spectrometric adductomics and an in vivo host cell reactivation assay to define the spectrum of DNA adducts in human cells, identify adducts that accumulate in senescing cells and drive replication stress, assess how...
- The National Institute on Aging awarded the University of Massachusetts Medical School $693,825 under the Aging Research program (CFDA 93.866) on September 15, 2026, to conduct research on somatic mutations in the human brain in Parkinson's disease. The project applies novel molecular and bioinformatic methods to study single neuronal genomes and somatic mutation in postmortem human brain tissue at unprecedented resolution. The research investigates the causes and functional consequences of...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $463,000 under the Aging Research program (CFDA 93.866) on May 1, 2026, to support research investigating chromatin mechanisms of cytoplasmic chromatin fragments during senescence and aging. The research examines how chromatin fragments transit from the nucleus to the cytoplasm in senescent and aged cells, activating the cGAS-STING immune pathway and driving chronic...
- This $1,039,863 National Institutes of Health National Institute on Aging project grant funds research at Harvard Medical School to reverse engineer the process of cellular senescence. The research will use new microscopy techniques to observe cell size changes and correlate protein expression and phosphorylation with senescence markers as cells transition from normal to senescent states in vitro and in vivo in young and aged mice. The same induction-maturation-death lifecycle will be studied...
- The National Institute on Aging awarded the President and Fellows of Harvard College $683,924 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on patient outcomes and healthcare utilization in U.S. hospices following private equity acquisition. The research examines how private equity acquisition affects hospice patient selection, length of stay, service utilization, live discharge rates, and Medicare spending. The study uses a quasi-experimental approach...
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $690,898 on September 15, 2026, under the Aging Research program (CFDA 93.866) to conduct functional genetic analyses of healthspan in humans. The recipient will identify shared genetic architecture underlying age-related diseases and aging-related traits, experimentally validate the regulatory roles of healthspan-associated non-coding variants and their target genes, and elucidate molecular...
The National Institute on Aging awarded the President and Fellows of Harvard College $125,901 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a universal toolkit for single-cell somatic mutation detection and apply it to aging-related processes. The project addresses the challenge of detecting post-zygotic somatic mutations that accumulate throughout life and may contribute to aging and disease. While single-cell whole genome sequencing and duplex sequencing techniques have emerged to study these rare mutations in healthy aging tissue, existing methods generate substantial artifacts or provide incomplete genome coverage. The award funds development of improved computational methods to accurately analyze single-cell whole genome sequencing data, distinguishing true aging-associated mutations from sequencing errors and enabling identification of mutations present in the same cell. Harvard Medical School, operating through Harvard College's Office of Research Administration, is the recipient. Performance occurs in Boston, Massachusetts. The period of performance runs from September 1, 2026, through August 31, 2028. This is a project grant, the standard NIH research funding mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.9k | 9/1/26 |