Project Grant R01AG097675
Award Date 9/15/26
Completion Date 6/30/31
Dollars Obligated $694K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Worcester, MA 01655, USA
Similar Awards
- The National Institute on Aging awarded the University of Massachusetts Medical School $452,783 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate molecular mechanisms of neuronal cell death and protection against neurodegeneration. The award funds research into how context-specific molecular mechanisms protect neurons against age-related degeneration, using C. elegans models of excitotoxicity and oxidative stress. The project will determine how TIR-1/SARM1, a...
- The National Institute on Aging awarded University of Massachusetts Medical School $445,130 on January 1, 2026, under the Aging Research program (CFDA 93.866) to support research elucidating the mechanisms by which MS4A genes regulate neurodegeneration in Alzheimer's disease and related disorders. The research investigates how genetic deletion and polymorphisms of MS4A family genes—particularly MS4A6C, MS4A4A, MS4A4E, and MS4A6E—affect disease progression across multiple neurodegenerative...
- The National Institute on Aging awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $677,276 on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct PET imaging research of alpha-synuclein pathology in neurodegenerative disease. The project will evaluate whether fibrillar alpha-synuclein burden measured with [11C]SY08 PET imaging differentiates dementia with Lewy bodies, Parkinson's disease, and multiple systems atrophy from each...
- The National Institute on Aging awarded Northwestern University $457,112 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of toxic short RNAs (sRNAs) and the DISE (Death Induced by Survival Elimination) mechanism in neurodegenerative diseases, particularly Alzheimer's disease and Huntington's disease. The research examines how G-rich sRNAs target survival genes through miRNA-like pathways and explores why normal tissues remain protected from this cell...
- The National Institute on Aging awarded the University of Massachusetts Medical School $452,783 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop genetically encoded intrabodies that inhibit individual enzymatic domains of retrotransposons in order to define retrotransposon function in synaptic development. The project addresses a critical gap in functional genomics: traditional loss-of-function approaches such as gene knockout and RNA interference cannot decouple...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease (AD). The $460,625 grant will fund research at the University of Massachusetts Medical School to dissect the separate P53/P21 and P16 senescence pathways and their functional consequences in AD using human induced pluripotent stem cell-based models. The 2-year project will produce...
- The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Medical School $542,777 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to discover and functionally analyze somatic mutations contributing to sporadic amyotrophic lateral sclerosis. The research combines clinical expertise in ALS genetics with expertise in somatic mutations and single-cell analysis to investigate...
- The National Institute on Aging awarded the University of Massachusetts Medical School $456,703 in a Project Grant (R21AG098673) effective July 1, 2026, under the Aging Research program (CFDA 93.866). The award funds basic biomedical research investigating neuronal mechanisms that direct stress-responsive transcriptional programs in response to oxidative damage. The work identifies oxidative stress response pathway genes regulated by the nervous system and uncovers neural signaling mechanisms...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded University of Massachusetts Medical School $3.32M through the Aging Research program (CFDA 93.866) on August 15, 2025, for a four-year research project concluding July 31, 2029. The award supports collaborative research by the Bosco and Massi laboratories investigating the molecular mechanisms underlying profilin-1 (PFN1)-mediated amyotrophic lateral sclerosis (ALS), a uniformly lethal neurodegenerative disease. The...