The National Institute on Aging awarded a $1,931,965 Project Grant (CFDA 93.866 - Aging Research) to the Regenerative Research Foundation to develop and validate a novel 3D human cell model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, pericytes, and microglia derived from induced pluripotent stem cells (iPSCs). The goal is to create an improved model for studying the cerebrovascular interactions underlying Alzheimer's disease-related dementias (ADRD), as current...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research provides $2,288,327 to the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The research aims to better understand the intersection of polygenic risk factors, biological aging, and key molecular pathways that initiate and drive MCI, with the goal of...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded Neucyte Inc. a $500,000 Project Grant to develop a nanoluciferase-based microphysiological systems platform for high-throughput screening of potential Alzheimer's disease (AD) and AD-related dementia (ADRD) therapeutics. The project aims to create a scalable, reproducible "mini-brain" assembled organoid (assembloid) model using AD patient-derived and gene-edited induced...
This $460,625 Project Grant awarded by the National Institute on Aging under CFDA Program 93.866 (Aging Research) aims to gain a mechanistic understanding of the role of cellular senescence in the pathogenesis of Alzheimer's disease. The grant supports research using human induced pluripotent stem cell-based Alzheimer's disease models to dissect the functional consequences of activating the p53/p21 and p16 senescence pathways in differentiated cortical neurons and cerebral organoids. The goal is...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $328,000.00 to The Regents of the University of California, San Francisco (UCSF) to conduct the "Alzheimer's Disease Organelle Proteome Task (ADOPT) - Pilot Phase" research project. The goal is to quantitatively measure the organelle proteome, including protein abundance, modifications, and complexes, to better understand organelle homeostasis and function in brain tissues during...
This Project Grant award of $205,619 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to map the landscape of the aged human brain to develop neurodegenerative disease models. The University of Washington will lead this two-phase research effort. In the first R21 phase, the team will perform proof-of-concept experiments to modulate the expression of machine learning-identified genes in human induced pluripotent stem cell (iPSC)-derived neurons and glia, and assess...
This $500,000 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) will support Sxrna Technologies, Inc. in developing an organoid toolkit for Alzheimer's disease (AD) and Alzheimer's-disease-related dementias (ADRD). The company aims to create a platform for identifying senescent cells in living tissue, which can provide insights into the aging process and enable high-throughput drug screening in complex 3D tissue models. Specifically, the grant will fund...
This Project Grant award of $1,145,500 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, San Diego supports research to understand the mechanisms by which hematopoietic stem cell transplantation can rescue Alzheimer's disease (AD) using the 5XFAD mouse model. The key objectives are to: Assess the impact of 5XFAD hematopoietic stem/progenitor cells (HSPC) on microgliosis and neuroinflammation in wild-type mice. Examine the hematopoietic lineage...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,667,706 to Emory University for research understanding the functional impacts of amyloid-β variants in Alzheimer's disease using human brain organoids. The three-year award beginning August 1, 2022 will support combining expertise in brain organoid modeling, spectroscopic analysis, and cryo-electron microscopy to identify strain-specific patterns of...
The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), has awarded a $2,112,826 cooperative agreement to the University of California, San Diego (UCSD) to advance a CRISPR-based therapeutic for Alzheimer's disease (AD) towards pre-IND stage. The project aims to determine the optimal gene-editing combination to edit the APP gene, which plays a central role in AD pathogenesis, and shift the APP cleavage pathway from pathologic to physiologic. UCSD will evaluate...