This $427,625 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The grant was awarded to The Washington University in St. Louis to support research evaluating novel transcription factors that regulate astrocyte identity, reactivity, and their roles in the pathogenesis of Alzheimer's disease (AD) and Parkinson's disease (PD). The research aims to systematically evaluate 10 candidate transcription factors identified...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,055,313 in funding to the University of Miami to conduct research on the role of glial cells in the aging process. Specifically, the researchers will leverage C. elegans genetics and advanced imaging and supplementation methods to investigate how the glial ion channel CLH-1 controls organismal aging. The key objectives are to establish the function of glial CLH-1 in influencing aging and to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to identify the molecular mechanisms underlying the conversion of glial cells into functional new neurons in the aged adult brain. The $126,956 award, effective April 1, 2025 through February 28, 2027, will enable the University of California, San Diego to utilize single-cell spatial transcriptomics technology to systematically map the cellular pathways and molecular events involved...
This $1,425,000 project grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into neuronal senescence and inflammation in Alzheimer's disease. The Salk Institute for Biological Studies will study the interaction between cellular senescence and inflammation in induced neurons derived from Alzheimer's patients and healthy aged controls. Researchers will examine differences in gene expression and epigenetic...
This federal Project Grant award, with ID R01AG085398, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award totals $2,181,876 and will be performed between Sep 15, 2024 and May 31, 2029 by the University of Oklahoma Health Sciences Center. The key products and services to be delivered under this award aim to investigate the role of astrocyte mitochondrial function and proteostasis in driving cognitive impairment...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,086,563 to The Trustees of the University of Pennsylvania to conduct research on the regulation of autophagy and lysosomal pathways in astrocytes and neurons in response to proteotoxic stress associated with alpha-synucleinopathies. The goal is to define the cell-type-specific differences in how quality control pathways are managed in neurons versus astrocytes, which may explain the increased...
This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
The National Institute on Aging (NIA) awarded a $107,865 Project Grant under the Aging Research Federal Grant Program (CFDA 93.866) to Cedars-Sinai Medical Center in California. The grant, awarded on August 1, 2024, aims to establish the novel concept of "reactive astrocyte memory" (RAM) and determine its functional consequences in Alzheimer's disease. The research will use mouse models to define RAM at the molecular level, test the contribution of RAM to Alzheimer's disease onset...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $461,146 to Yale University to conduct research on the dysregulation of cortical astrocytes in models of Alzheimer's disease. The research aims to: Assess the early loss of state-dependent spatiotemporal dynamics of astrocytic signaling as an initial consequence of Alzheimer's pathology. Investigate the progressive loss of coupling between noradrenergic signaling and astrocyte activity due...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $688,419 to The Research Foundation for The State University of New York, doing business as Stony Brook University, to study the regulation of astrocyte glucose metabolism and lactate production by hippocampal neural activity, and their impact on the survival of newly generated neurons in adult hippocampal neurogenesis. The 5-year project aims to uncover the interplay between neuronal...