Project Grant K23AG097948
- Federal Grant Award Summary The National Institute on Aging awarded the University of Pittsburgh a $2.0 million Project Grant (CFDA 93.866: Aging Research) effective September 15, 2025, through August 31, 2029, to investigate white matter injury in Alzheimer's disease (AD). The research will characterize risk factors and consequences of white matter injury in brain regions affected by AD pathology using a novel measurement method called Unhealthy White Matter Connectivity (UWMC). The study...
- The University of Pittsburgh received a $664,619 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This award funds development of multiscale computational and imaging models of neurometabolic coupling—the relationship between neural activity and brain metabolic processes—with specific focus on age-related changes and late-onset Alzheimer's disease. The research employs advanced in vivo...
- Federal Grant Award Summary The University of Pittsburgh received a $801,268.00 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2030. This five-year research initiative focuses on developing real-world and innovative multimodal prediction and prevention approaches for postoperative mortality and multi-morbidity in elderly surgical patients. The project addresses a critical public health need by...
- Federal Grant Award Summary The University of Pittsburgh received a $453,932 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 1, 2026 through January 31, 2028. The grant funds development of a narrative video game intervention designed to improve advance care planning (ACP) for persons living with dementia and their care partners. The intervention addresses two key cognitive biases that impede effective ACP...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $424,913 Project Grant to the University of Pittsburgh under the Aging Research program (CFDA 93.866) for the period July 1, 2026 through June 30, 2028. This R21 exploratory grant funds research investigating human entorhinal cortex (EC) LAMP5 interneurons—a specialized neuronal subtype implicated in cognitive decline associated with Alzheimer's disease (AD). The research deliverables include characterization...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a K23 Career Development Grant of $162,020 to the University of Pittsburgh under the Aging Research program (CFDA 93.866) beginning August 5, 2025, and extending through July 31, 2030. This grant supports the career development of Dr. Nami Safai Haeri, a geriatrician and endocrinologist, to conduct research examining the effects of osteoporosis medications on muscle health in older adults. The research leverages data...
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
- Federal Grant Award Summary The University of Pittsburgh received a $433,710 Project Grant award from the National Institute on Aging (CFDA 93.866 – Aging Research) effective February 15, 2026, through January 31, 2028, to develop and optimize epigenetically modified replication-defective herpes simplex virus (RDHSV) vectors for multigenic gene therapy targeting Alzheimer's disease. The primary deliverable is advancement of the RDHSV vector platform as a novel therapeutic delivery system capable...
- Federal Grant Award Summary The University of Pittsburgh received a $3.1 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2029. This award supports biomedical research investigating the mechanistic relationship between persistent DNA damage-induced immune responses and aging. Specifically, the research examines how the cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes)...
- Federal Grant Award Summary The National Institute on Aging awarded a K23 (Mentored Patient-Oriented Research Career Development) grant of $145,706 to the University of Miami's Office of Research Administration—School of Medicine on July 1, 2026, under the Aging Research program (CFDA 93.866). This award supports both research and structured career development training for a clinical sleep neurologist through April 30, 2031. The grant delivers a comprehensive training framework consisting of...
Grant Award Summary The University of Pittsburgh received a $190,088 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded July 1, 2026, with a completion date of March 31, 2031. This K23 career development award funds research investigating the relationship between sedentary behavior and Alzheimer's disease (AD) and Alzheimer's disease and related dementias (ADRD) risk. The project will deliver comprehensive research products including: (1) empirical analysis of associations between sedentary behavior and cognitive function using neuropsychological assessment across three deeply phenotyped aging cohorts at the University of Pittsburgh; (2) evaluation of links between sedentary behavior and AD biomarkers measured through positron emission tomography (PET) imaging and blood-based biomarkers; and (3) isotemporal substitution analyses predicting changes in longitudinal cognition and ADRD biomarkers under scenarios substituting sedentary time with activity time. The research addresses a significant public health gap by elucidating neurobiological pathways through which sedentary behavior independently contributes to AD/ADRD risk, thereby informing non-pharmaceutical prevention strategies for a disease category with limited pharmaceutical treatment options. Deliverables will include peer-reviewed publications, investigator career development, and mechanistic insights into modifiable health behaviors as biological targets for early dementia prevention.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $190.1k | 7/1/26 |