This $2,327,075 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research at Baylor College of Medicine to investigate the role of the complement pathway and receptor C3AR in regulating microglia metabolism and function in Alzheimer's disease (AD). The key objectives are to: 1) Understand how the C3AR-HIF-1A pathway impacts microglia metabolic state and receptor trafficking in response to amyloid-beta pathology, 2) Decipher the relationship between...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,147,300.00 to Wayne State University to investigate how pathogenic forms of the tau protein interfere with dendritic protein synthesis in Alzheimer's disease models. The research aims to understand the early synaptic dysfunction caused by tau pathology, with the goal of identifying molecular targets for intervention before the irreversible loss of synapses and neurons in Alzheimer's...
This federal Project Grant award of $1,055,595 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to better understand how advancing age contributes to the occurrence and progression of Alzheimer's disease (AD). The key objectives are to: 1) determine how increasing endosome formation, the vehicles for endosome trafficking, can decrease tau protein accumulation in neurons, a hallmark of AD pathology; and 2) define how increasing endosome formation influences cognition and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify mechanisms that confer cognitive resilience to Alzheimer's disease pathology. The $1,003,116 award to the University of Alabama at Birmingham aims to determine whether resilient individuals have less pathogenic tau proteins in synaptic compartments or are their synapses more resilient to tau accumulation. The research will seek to identify synaptic proteins and...
This Project Grant award, issued by the National Institute on Aging under CFDA 93.866 - Aging Research, aims to elucidate the molecular mechanisms underlying the neurodegenerative reprogramming of microglia, the brain's resident immune cells, in Alzheimer's disease (AD). The $442,357 grant will fund research to determine how cellular stress signaling pathways, specifically the Integrated Stress Response (ISR), epigenetically reprogram microglia in a way that exacerbates their neurodegenerative...
This federal Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $169,560 to the Regents of the University of Michigan to research ways to reverse neural network dysfunction in Alzheimer's disease (AD) and related dementias. The key objectives are to: Identify disrupted gene expression in inhibitory interneurons within the hippocampus and cortex of human AD brains to uncover therapeutic targets for restoring cognitive function....
This $1,100,000 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to the University of Texas Medical Branch at Galveston (UTMB). The project aims to investigate the mechanisms by which amyloid-beta (Aβ) modulates the binding and internalization of pathogenic tau oligomers in human synapses, a key component of the trans-synaptic spread of tau pathology in Alzheimer's disease. Using innovative techniques to directly...
This $1,010,081 federal Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports a multi-year research project by Emory University focused on identifying potential "goldilocks zone" immune modulatory therapies for Alzheimer's disease. The overarching goal is to systematically evaluate the liabilities and benefits of different immune system manipulations in preclinical models of amyloid pathology, with the aim of finding interventions that...
The National Institute on Aging awarded a $10,847,672 Project Grant (CFDA 93.866 - Aging Research) to the J. David Gladstone Institutes in San Francisco, CA. The grant funding will support a comprehensive scientific investigation into the mechanisms underlying cerebral amyloid angiopathy (CAA) and its relationship to Alzheimer's disease pathology. The research will utilize human postmortem brain samples, single-cell genomic profiling, and mouse models to elucidate the role of microglia in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $498,748.00 to the University of Massachusetts Medical School (UMass Medical) to elucidate the mechanisms by which MS4A genes regulate neurodegeneration in Alzheimer's disease and related disorders. The project aims to investigate the effects of deleting other MS4A family members, individually or in combination, on neurodegenerative phenotypes in mouse models. Additionally, the research will...