This $239,758 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the development of a microphysiological system that models the brain-meninges-lymph node axis in both healthy conditions and an Alzheimer's disease model. The primary awardee, Virginia Polytechnic Institute & State University, will integrate tissue-engineered models of the human brain, lymph node, and meninges into a microfluidic platform to enable the study of neuroimmune...
This federal Project Grant award of $2,027,220 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of major histocompatibility complex I (MHC-I) in regulating microglial function and T cell infiltration in the context of brain aging and Alzheimer's disease. The research, conducted by the Oklahoma Medical Research Foundation, aims to determine if microglial MHC-I expression modulates reactivity, phagocytic phenotypes, and T cell...
This federal Project Grant award, funded by the National Institute on Aging (part of the Department of Health and Human Services) under the Aging Research program (CFDA 93.866), is focused on evaluating a novel therapeutic approach to target neuroinflammation for protecting against brain aging and Alzheimer's disease-related pathology. The $281,962 award, with an end date of June 30, 2026, will support a series of preclinical studies in aging wild-type mice and transgenic mouse models of amyloid...
This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to investigate the roles of cellular senescence and blood-brain barrier dysfunction in Alzheimer's disease development and progression. The key objectives are to understand how viral and bacterial infections can initiate blood-brain barrier impairment and increase inflammation, leading to accelerated Alzheimer's disease pathology. The research...
This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $191,891 to the University of Washington to support research aimed at improving the understanding of early microglial dysfunction in Alzheimer's disease (AD). The key objectives are to integrate novel explainable AI techniques with deep learning methods to better distinguish AD-specific microglial changes from general aging effects, and to model the impact of AD-related stimuli and...
This Project Grant award of $418,000.00 from the National Institute on Aging's Aging Research Program (CFDA 93.866) aims to elucidate the role of B cells and antibodies in the pathophysiology of aging and associated neurodegeneration. The key objectives are to analyze the immunoglobulin repertoire and phenotypic nature of B cells in the cerebral spinal fluid (CSF) compared to peripheral blood B cells in young and old people. This will determine the extent to which peripheral B cells migrate to...
This Project Grant award, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will support the development of a novel, allogeneic cell-based therapy to address both tau-mediated pathology and associated inflammation in Alzheimer's disease and related dementias. The $734,778.00 grant awarded to the Regents of the University of Minnesota will fund research to engineer human induced pluripotent stem cell-derived macrophages with chimeric antigen receptors...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to evaluate a novel molecular intervention to reverse the dysregulation of calcium/calmodulin-dependent protein kinase II alpha (CaMKIIα) and related pathological changes in Alzheimer's disease models. The $644,915 award, effective September 1, 2024 through May 31, 2026, will support research by Wayne State University to investigate if adeno-associated virus (AAV)-mediated delivery of CaMKIIα...