Project Grant R01AG092960
Award Date
6/15/25
Completion Date
3/31/30
Dollars Obligated
$1.6M
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
Similar Awards
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to examine cerebrospinal fluid (CSF) and blood biomarkers that may provide insights into the pathways leading to postoperative delirium and neurocognitive dysfunction. The $805,295 award to The Leland Stanford Junior University will fund a 3-center study of 180 patients undergoing aortic surgery, collecting serial CSF and blood samples over 2-3 days. The goal is to determine if biomarkers...
This $326,797 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) aims to use proteomic analyses to identify plasma proteins and protein networks associated with mild cognitive impairment in people with type 2 diabetes. The primary goal is to uncover potential biomarkers that could help predict risk of cognitive impairment syndromes in this population. The study will examine differences in plasma proteins between people with type 2 diabetes who do...
This National Institute on Aging (NIA) Project Grant award (CFDA 93.866 - Aging Research) provides $180,252 to Duke University from August 15, 2024 to May 31, 2029 to determine the role of cerebrospinal fluid (CSF) complement activation in postoperative delirium, intensive care unit (ICU) delirium, and post-ICU long-term cognitive impairment. The project aims to leverage a CSF biorepository and recruit a cohort of 120 older ICU patients to measure CSF complement activation and discover other...
The National Institute on Aging (NIA) awarded a $2,415,422 project grant (CFDA 93.866 - Aging Research) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the role of perineural nets (PNNs) in the pathogenesis of postoperative delirium (POD) in older adults. The key objectives are to: 1) examine the kinetics of neuroinflammation-mediated PNNs degradation after anesthesia and surgery; 2) evaluate if depleting PNNs surrounding parvalbumin...
This Project Grant from the National Institutes of Health National Institute on Aging provides $4,489,362 to Duke University from September 15, 2022 through August 31, 2025 under the Aging Research program (CFDA 93.866). The grant will fund research to identify mechanisms of blood-brain barrier dysfunction in delirium superimposed on dementia after surgery. Specifically, the researchers will characterize how the postoperative systemic environment impacts the blood-brain barrier using...
This $15,046,454 project grant from the National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at the University of California, San Diego to improve understanding of proteomic changes preceding Alzheimer's disease and related dementias. The research will analyze longitudinal plasma samples from 2,836 women in the Women's Health Initiative Memory Study cohort using the Somamscan proteomics platform to identify novel...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Duke University is focused on investigating the impact of hypertension and aging on postoperative delirium. The $715,801 award, effective June 1, 2025 through March 31, 2030, aims to elucidate the specific contributions of endothelial cells and perivascular macrophages to surgery-induced neuroinflammation, blood-brain barrier disruption, and delirium-like behavior in aging and hypertension....
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,245,769 to Pascall Systems, Inc. to develop an integrated brain state monitoring system for personalized anesthesia decision support. The project aims to prevent postoperative delirium in elderly patients and those at risk for Alzheimer's or related dementias. Key objectives include: 1) establishing technical feasibility in connecting the monitoring system with electronic medical records,...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to investigate the use of dried blood spot (DBS) samples for measuring Alzheimer's disease (AD) biomarkers. The $459,250 award to The General Hospital Corporation (Massachusetts General Hospital) aims to: 1) optimize fingerstick collection methods and validate assays for measuring key AD biomarkers (pTau217, GFAP, NFL) in capillary DBS samples; 2) establish if DBS biomarker...
This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) will investigate proteomic biomarkers for cognitive and brain changes associated with Alzheimer's disease and related dementias (AD/ADRD). The 5-year, $4.62M project will measure over 7,000 proteins and established AD/ADRD biomarkers in the Lothian Birth Cohort 1936 at ages 73, 76, 82, and 85 years. The study will use growth curve and survival models to test associations between biomarkers and...