Project Grant K22AG095317
- Federal Project Grant Award Summary Rutgers, The State University received a $431,750 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded June 1, 2025, with completion targeted for May 31, 2027. The award supports research investigating the role of mitochondrial deficits in tauopathy-linked autophagy defects as they relate to Alzheimer's disease pathology. The research focuses on understanding how early mitochondrial abnormalities,...
- Federal Grant Award Summary The National Institute on Aging awarded The University of Texas Health Science Center at San Antonio a $433,125 exploratory/developmental project grant on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the role of extracellular tau protein in modulating neurogenesis through the LRP1 (Low-Density Lipoprotein Receptor Related Protein 1) pathway. The research project, with an ultimate completion date of August 31, 2027, will deliver...
- Federal Grant Award Summary New York University received a $422,297 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 15, 2026, with a completion date of January 31, 2028. The award supports biomedical research investigating the mechanisms by which Frontotemporal Dementia (FTD)-associated tau mutations dysregulate protein synthesis in human neurons. The research utilizes human induced pluripotent stem cell (iPSC)-derived neurons carrying...
- Federal Project Grant Award Summary Rutgers The State University of New Jersey, School of Nursing, received a $639,838 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded December 15, 2025, with completion anticipated by November 30, 2030. The research focuses on investigating the role of amyloid precursor protein (APP) metabolites in extracellular vesicle (EV) cargo and function as they relate to Alzheimer's disease pathogenesis. The project will...
- Federal Project Grant Award Summary Rutgers, The State University received a $573,035 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded February 15, 2026, with completion targeted for January 31, 2031. The award supports research investigating the cellular mechanisms by which the mechanosensitive ion channel PIEZO1 controls cerebrospinal fluid (CSF) hydrodynamics and brain-waste clearance. The research will elucidate how pharmacological...
- Federal Project Grant Award Summary The University of Illinois received a $1,592,854 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 1, 2025, through May 31, 2027. This award funds research investigating tau protein conformation in tauopathies, including Alzheimer's disease and related dementias such as progressive supranuclear palsy, cortical basal degeneration, and chronic traumatic encephalopathy. The research centers on...
- Federal Grant Award Summary Rutgers The State University of New Jersey, through its RBHS-School of Nursing, received a $109,076 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 23, 2025, with a completion date of September 22, 2029. While the specific research objectives are not detailed in the available award documentation, this funding supports biomedical or behavioral research directed toward understanding the aging...
- Federal Project Grant Award Summary Ohio University received a $567,256 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to investigate the mechanisms of activity-dependent tau protein release and its role in Alzheimer's disease (AD) pathogenesis. The award, effective February 1, 2026, through January 31, 2029, supports research designed to elucidate how neuronal hyperexcitability triggers the release of tau into the extracellular space,...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Texas Medical Branch at Galveston $1,112,821 under the Aging Research program (CFDA 93.866) for a five-year project period spanning January 1, 2026, through December 31, 2030. This Project Grant supports biomedical research investigating the interplay between microglia activation and tau oligomer polymorphs in cognitive resilience among Alzheimer's disease patients. The research focuses on...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant of $681,908 to The Regents of the University of California, San Francisco on February 15, 2026, under the Aging Research program (CFDA 93.866). The award supports a research project titled "Mechanisms of Protective UFM1-Dependent IRE1 Signaling in Tauopathies," with performance conducted in San Francisco, California, through November 30, 2030. The research focuses on understanding how...
Rutgers, The State University received a $225,256 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective May 1, 2026 through April 30, 2029. The award supports basic neuroscience research investigating the protective role of Big Tau, a structurally distinct tau protein isoform, in preventing tau pathology associated with Alzheimer's disease. The research will deliver scientific knowledge regarding the mechanisms by which Big Tau resists pathological changes such as aggregation and hyperphosphorylation that characterize standard tau isoforms, and will examine which structural features of Big Tau contribute to its neuroprotective properties. The project will produce empirical data through multiple research approaches, including biochemical characterization of Big Tau's protein structure and functional properties, proof-of-concept studies using novel transgenic mouse models expressing Big Tau instead of endogenous mouse tau, neuronal culture experiments demonstrating Big Tau's capacity to suppress tau pathology, and analysis of human postmortem brain tissue. Findings will contribute to the identification of therapeutic targets and intervention strategies aimed at upregulating Big Tau expression as a potential disease-modifying approach for Alzheimer's disease, thereby supporting the NIA's mission to advance prevention and treatment of age-related neurodegenerative diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $225.3k | 4/28/26 |