Project Grant R01AG097537
- This $433,125 Project Grant award was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to The University of Texas Health Science Center at San Antonio. The grant is designed to test the hypothesis that extracellular tau protein can modulate neurogenesis (the growth of new neurons) through the LRP1 receptor in the adult brain, with potential implications for understanding memory loss in Alzheimer's disease and related dementias. The research aims to provide novel...
- This Project Grant award of $1,592,854.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to understand the role of the tau protein in the development of Alzheimer's disease and related dementias. The central hypothesis is that pathogenic forms of tau represent a misregulation of tau's normal biological function as a scaffold for regulating signaling pathways. The research aims to define the effects of tau post-translational...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- This federal Project Grant award of $805,573 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project to investigate the impact of m6A RNA modifications in Alzheimer's disease and related tauopathies. The award was granted to the Regents of the University of California, San Francisco and runs from September 15, 2025 through June 30, 2030. The research aims to uncover specific RNA sites with differential m6A modifications in Alzheimer's and other...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $773,816 to the University of California, Irvine to conduct a research project titled "Cell-type-specific and Spatial Proteogenomics Analysis of Aberrant RNA Splicing and Misfolded Proteins in Alzheimer's Related Tauopathies". The project aims to use advanced spatial proteogenomics techniques to map aberrant RNA splicing and abnormal protein products in specific brain...
- This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866), aims to identify small molecule ligands that target pathological tau signaling in Alzheimer's disease (AD) and related dementias. The $3,336,256 award to the University of Illinois will fund research to develop a series of candidate molecules that can prevent the toxic effects of misfolded tau protein, which plays a central role in the pathogenesis of...
- This Project Grant award of $816,661.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to comprehensively map the impact of tau pathology on the proteome and measure the functional consequences in neurodegeneration associated with Alzheimer's disease and frontotemporal dementia. The project combines expertise in mass spectrometry-based proteomics and functional genomics to elucidate the molecular and cellular mechanisms by which pathological tau drives...
- This $130,302 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at New York University School of Medicine to investigate the selective vulnerability of basal forebrain cholinergic neurons (BFCNs) to tau pathology in Alzheimer's disease (AD). The key products and services to be delivered include: Investigating the biochemical underpinnings and functional alterations of BFCNs with pathological tau accumulation using human induced...
- This $165,348 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the cellular and molecular mechanisms underlying neurotoxicity and cognitive deficits caused by hyperphosphorylated tau protein, a hallmark of Alzheimer's disease. The grant recipient, the Rector & Visitors of the University of Virginia, will use a combination of transcriptomic profiling and neurophysiology approaches to characterize the effects of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The $784,596 grant aims to develop a state-of-the-art proteogenomic pipeline to globally profile disease-associated proteins, including those with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic cleavage products. The...
This federal Project Grant award of $548,723 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the relationship between unique tau oligomer polymorphs associated with resilience and specific phenotypes of activated microglia in Alzheimer's disease. The key objectives are to test the hypothesis that brain-derived tau oligomers (BDTOs) isolated from non-demented individuals with Alzheimer's neuropathology (NDAN) exhibit reduced toxicity compared to AD-BDTOs, and induce a distinct microglial phenotype that triggers an inflammatory response associated with resilience. The University of Texas Medical Branch at Galveston is the awardee for this project, which has a performance period from January 1, 2026 to December 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $548.7k | 12/23/25 |