This $126,568 Project Grant, awarded on September 12, 2024 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a novel, uterine-specific drug delivery system to treat preterm labor. The key products and services to be delivered through this funding include: Optimizing the physical-chemical parameters and antibody targeting of a poly(lactic-co-glycolic)...
This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 (Child Health and Human Development Extramural Research) aims to develop and evaluate water-soluble prodrugs of the novel therapeutic compound AKT-1005 for the treatment of preeclampsia. The $468,540 award to Beth Israel Deaconess Medical Center, Inc. (BIDMC) will fund research to synthesize and screen AKT-1005 prodrugs for improved solubility,...
This Project Grant award of $248,999 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to identify effective therapeutic agents for managing infection-induced preterm labor (III-PTL) and protecting against fetal inflammation. The key activities under this award include: 1) Optimizing a high-throughput screening assay to measure changes in pro-inflammatory cytokines...
The National Institute of Child Health and Human Development (NICHD) awarded a $427,625 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Washington University in St. Louis, Missouri. The grant aims to provide a mechanistic understanding of how maternal obesity affects uterine contractility and energy metabolism during labor and parturition. The researchers will use a mouse model of diet-induced obesity to investigate the impacts of excess fatty acids...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $485,925 to the University of Massachusetts Boston to develop novel antioxidant compounds for treating preeclampsia, a life-threatening pregnancy complication. The primary goal is to design and synthesize cationic hydrazone antioxidants that can target mitochondria to reduce oxidative stress, improve...
The National Institute of Child Health and Human Development (NICHD) awarded a $424,875 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Maryland, Baltimore (UMB) to investigate the role of placental serum amyloid A (SAA) isoforms in response to sub-chronic maternal inflammation and explore whether inhibition of the SAA2 isoform using small interfering RNA (siRNA) can alleviate preterm birth and adverse fetal outcomes. The project aims...
This federal Project Grant award, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 (Child Health and Human Development Extramural Research), supports research to evaluate the mechanisms of cell-free fetal DNA signaling in the promotion of labor. The $139,446 award, with a performance period from August 2024 to January 2025, will enable the grantee, Mayo Clinic, to pursue two key research objectives: 1) Evaluating...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $121,515 to Duke University to investigate nuclear plasticity in the human placental syncytium during pregnancy. The research aims to: 1) Determine the mechanism of nuclear subtype adaptation in the syncytiotrophoblast (STB) cell during stress, and 2) Map the unique...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA program 93.865, "Child Health and Human Development Extramural Research," provides $430,031.00 to evaluate the role of DNA methylation changes in very early preterm birth. The grant, awarded to Harvard T.H. Chan School of Public Health, will support research activities focused on understanding the complex biological mechanisms underlying preterm birth, a critical public...
The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...