Project Grant R21HD115117

Award Date 8/15/24
Completion Date 7/31/26
Dollars Obligated $263K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Boston, MA 02215, USA
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This National Institute of Child Health and Human Development (NICHD) Project Grant award, under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $262,808 to Beth Israel Deaconess Medical Center (Bidmc) to develop and test water-soluble prodrugs of the compound AKT-1005 for the treatment of preeclampsia.

The key products and services to be delivered through this funding include:

  • Synthesizing, screening, and evaluating the solubility, stability, and in vitro/in vivo drug release properties of AKT-1005 prodrug candidates
  • Conducting pharmacokinetic studies in rodents to determine systemic exposure of the parent prodrug, AKT-1005, and major metabolite after IV and IP dosing
  • Performing cross-species metabolic comparisons using isolated liver microsomes from multiple species
  • Evaluating the efficacy of the most promising prodrug candidates in a murine model of preeclampsia, measuring outcomes such as blood pressure, renal function, tissue damage, and biomarkers

The project aims to advance an optimized AKT-1005 prodrug as a clinical candidate for early intervention in high-risk preeclampsia pregnancies. The award period is from August 15, 2024 to July 31, 2026.

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