Project Grant R56EY037686
- The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $693,423 Project Grant on September 15, 2025 to the University of Mississippi Medical Center (UMMC) to develop a multivalent antibody cocktail for the treatment of bacterial endophthalmitis. The goal of this 1-year project is to translate prior research on ocular microbiology into a new drug that can be used in conjunction with antibiotics to combat damage and loss of retinal function caused by...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $586,258 project grant to Wayne State University to characterize the role of eosinophils in modulating the corneal response to Pseudomonas aeruginosa-induced infection. The 4-year project, commencing on July 1, 2025 and completing on April 30, 2029, aims to investigate the spatiotemporal distribution, phenotypic profiles, and proteomic changes of eosinophils during corneal infection. The...
- This $257,785 Project Grant was awarded on April 1, 2025 by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867). The grant supports the development of a refillable micromachined lens capsule-based drug delivery device for extended intraocular delivery of biologics and immune-modulating peptides to treat non-infectious uveitis. The key products/services to be delivered under this 4-year grant include: Characterizing and controlling the release of the...
- This $240,750 federal Project Grant award from the National Eye Institute's Vision Research program (CFDA 93.867) aims to investigate the role of neural-glial-vascular signaling in the development of the eye's vasculature. The research has two main objectives: 1) Characterizing vasculature development and how it is altered in mice with modified retinal waves, using quantitative approaches and live imaging, and 2) Establishing the maturation of the glial-vascular unit through immunofluorescence...
- This $148,568 Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research at Emory University to investigate the role of scleral fibroblasts in refractive development and myopia. The primary objectives are to: 1) Identify characteristics of scleral fibroblasts in mouse eyes that undergo normal refractive development versus those exposed to myopic stimuli, and 2) Determine the role of retinoic acid signaling in driving...
- This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $127,861 to The Regents of the University of California, Berkeley to conduct research on the role and regulation of a distinct optic nerve microglia population in glaucomatous neuropathy. The research aims to elucidate how the lipoxin LXB4 regulates disease-associated microglia (DAM) in the optic nerve during ocular hypertension, a key mechanism in the neuroprotective effects of LXB4 against...
- This $417,162 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research on using optical techniques to detect early signs of glaucoma, the leading cause of irreversible blindness worldwide. The University of Houston System, the grantee, will conduct research to determine if changes in the birefringence (optical properties) of the lamina cribrosa and posterior eye structures can serve as sensitive early indicators of glaucoma before structural damage...
- This $332,179 Project Grant awarded by the National Eye Institute (CFDA 93.867 Vision Research) supports the development of nanobarrier contact lenses that can provide sustained delivery of the drug cysteamine to treat the ocular complications of cystinosis. The lenses are designed to replace the current 8-times daily eye drop regimen, improving patient compliance and reducing side effects from the preservatives and acidic pH in the eye drops. The project aims to demonstrate the lenses can...
- This Project Grant award of $253,500.00 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research by the Icahn School of Medicine at Mount Sinai to reconstruct a human blood-retina barrier and perfused vascular system. The goal is to investigate the role of apolipoprotein E (APOE) variants in age-related macular degeneration (AMD), a leading cause of vision loss. The researchers will optimize an in vitro human outer blood-retina barrier model to study AMD phenotypes and...
- This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to develop universally immune-compatible induced pluripotent stem cells (iPSCs) for regenerative therapies to treat various eye conditions. The $492,500 award, granted on January 1, 2025, supports research at The Schepens Eye Research Institute, Inc. to generate iPSCs that express peptide-free or low-affinity peptide-loaded HLA-I molecules, protecting them from...
This Project Grant award of $715,000 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research into the mechanisms by which bacterial pathogens use polysaccharide capsules to evade the immune system during ocular infections, a leading cause of blindness worldwide. The research, conducted by the University of Oklahoma Health Sciences Center, aims to investigate how these "cloaking" mechanisms allow antibiotic-resistant ESKAPE group bacteria to proliferate in the eye and cause severe retinal damage. The project will utilize animal models and ocular cell lines to elucidate the virulence factors and immune evasion pathways involved, with the goal of informing the development of new treatment strategies for these difficult-to-treat bacterial eye infections. The award period runs from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $715.0k | 8/25/25 |