This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $423,500.00 to Nova Southeastern University, Inc. to develop a humanized mouse model of periodontitis. The goal is to investigate the potential pathogenic role of the protein Semaphorin 4D expressed by human osteoclasts in the progression of periodontal disease. This advanced mouse model will allow researchers to...
This federal Project Grant award of $311,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Washington. The goal of the project is to employ single-cell RNA sequencing to characterize the microbial and inflammatory state within clinically healthy tissues of patients with active periodontal disease. Specifically, the project aims to resolve key differential signaling...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $645,009 to the Augusta University Research Institute, Inc. to investigate the role of osteocyte NOD1 signaling in bone loss associated with periodontal disease. The key objectives are to: 1) determine if osteocytes use the NOD1 receptor to recognize periodontal pathogens and induce the bone resorption...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $446,875 to support research on the role of a novel G protein-coupled receptor, MRGPRX2, in the development of periodontal disease. The funded research aims to develop two humanized mouse models to study the contribution of MRGPRX2-expressing mast cells to Porphyromonas gingivalis-induced and ligature-induced...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop novel therapies for endogenous periodontal regeneration. The $1,705,144 award to the University of Pittsburgh will fund research to 1) identify specific cell surface markers to isolate and characterize human PRX1-expressing periodontal stem cells, 2) develop a strategy to harness these stem cells for complete...
This Project Grant award of $588,952 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is focused on developing a bio-inspired scaffold called "PerioPatch" to regenerate Sharpey's fibers and periodontal tissues. The key objectives are to: 1) develop and optimize a tubular matrix to guide periodontal ligament (PDL) principal fiber formation, 2) rebuild the microenvironment for Sharpey's fiber...
This federal Project Grant award of $248,999 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the role of CD4+ memory T cell subtypes in periodontal disease recurrence. The primary objectives are to: 1) identify the spatiotemporal development of CD4+ memory T cells in periodontal tissues, 2) elucidate the pathogenicity of periodontal disease-induced CD4+ memory T cell subtypes,...
This Project Grant award of $858,000 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research to explore the mechanisms by which the bacterium Veillonella inhibits the hemolytic activity of the periodontal pathogen Porphyromonas gingivalis. The research aims to: 1) investigate how Veillonella's heme production suppresses P. gingivalis' hemolysis, and 2) determine how P. gingivalis regulates...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $432,209 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) for a 2-year period starting on August 1, 2023. The funding supports research to investigate the role of the CXCL10-CXCR3 axis in the compounding effects of diabetes mellitus on periodontitis. Specifically, the research aims to further elucidate the role of CXCL10 in the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $762,432 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) in Augusta, GA. The project, titled "Metabolic-Purinergic Fitness in Periodontal Health and Disease", aims to investigate the role of the enzyme CD73 in controlling inflammation and bone loss associated with periodontal disease. The...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $101,356 to Nova Southeastern University to conduct research on the role of the PIEZO1 mechanosensitive receptor in regulating type H vessel formation in periodontal disease. The research aims to demonstrate how activation of PIEZO1 on endothelial cells can polarize them towards a type H vessel phenotype, and to determine the impact of PIEZO1 on type H vessel formation in a mouse model of periodontitis. The award period runs from September 1, 2025 to August 31, 2028. The research findings are expected to lay the groundwork for a future R01 grant application and potential paradigm shift in the understanding and treatment of periodontal diseases.