Project Grant K08AG097113
- The National Institute on Aging awarded the University of California, Berkeley $598,837 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate how hematopoietic stem cell aging affects distant tissues and organismal aging. The research will characterize a mouse model that reverses hematopoietic stem cell (HSC) aging by measuring changes in healthspan and lifespan and deciphering the molecular and cellular mechanisms underlying those alterations. The work tests the...
- The National Heart, Lung, and Blood Institute awarded the University of California, San Diego $1,601,981 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate protein aggregation mechanisms in hematopoietic stem cells and their relationship to stem cell aging. The research examines how hematopoietic stem cells traffic misfolded proteins to aggresomes—cytosolic inclusion bodies that are substrates for selective autophagy—and tests the hypothesis...
- The National Institute on Aging awarded The Leland Stanford Junior University $667,539 on September 1, 2026, under the Aging Research program (CFDA 93.866) to support research on mechanisms of brain repair during aging, with the objective of preventing Alzheimer's disease and Alzheimer's disease-related dementia. The research characterizes neural stem cells (NSCs) during injury and aging to identify interventions that boost repair in aging brains. NSCs reside in specific brain regions...
- The National Heart Lung and Blood Institute awarded Brigham & Women's Hospital Inc. $402,750 under Project Grant R21HL184189 on April 1, 2026, to conduct integrative single-cell analysis of aging-associated changes in human hematopoietic stem cell heterogeneity. The award funds two specific aims: identifying age-associated changes in hematopoietic stem cells (HSCs) across eleven existing datasets and determining how consensus gene expression programs shape HSC heterogeneity and relate to...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute on Aging awarded Dana-Farber Cancer Institute, Inc. $130,680 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic drivers of stem cell fitness in aging hematopoiesis. The research elucidates how disrupted DNA methylation drives the defective inflammatory response of TET2-mutant hematopoietic stem cells under chronic IL-6 treatment and contributes to their enhanced fitness in aging populations. Over 75% of individuals aged 70 and older...
- The National Institute on Aging awarded the University of Rochester $227,250 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate macrophage spatial heterogeneity in regulating hematopoietic aging and inflammation-related stem cell dysfunction. The research examines how resident macrophages in different bone marrow microenvironments regulate hematopoietic stem cell (HSC) division symmetry and fitness during aging. Using intravital microscopy and HSC reporter...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $1,468,868 on January 15, 2026, under the Aging Research program (CFDA 93.866, Program Grant R01AG097491) to investigate how the brain regulates organismal aging as a neural pacemaker controlling the tempo of aging across multiple organ systems. The research combines high-throughput longitudinal studies in killifish—a vertebrate model with a naturally compressed...
- The National Institute on Aging awarded $648,930 to the Regents of the University of California, doing business as University of California, Berkeley, on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop human stem cell-based microphysiological systems for aging research. The recipient will create a novel human aging-on-a-chip platform integrating fat and liver tissues derived from human induced pluripotent stem cells (hiPSCs) and microfluidics using serum from young...
- The National Institute on Aging awarded the University of Vermont & State Agricultural College $664,971 on February 15, 2026, under the Aging Research program (CFDA 93.866) to measure clonal hematopoiesis and its longitudinal impact on aging outcomes in a large prospective cohort study. The project measures clonal hematopoiesis—abnormal expansion of hematopoietic cell clones in the absence of hematologic abnormalities—in 30,239 participants enrolled in the Reasons for Geographic and Racial...
The National Institute on Aging awarded The Leland Stanford Junior University $165,887 on August 5, 2026, under the Aging Research program (CFDA 93.866) to conduct research on human adult hematopoietic stem cells through aging, inflammation, and clonal selection. The research addresses functional changes in aging hematopoietic stem cells (HSCs) and their role in maintaining blood cell production. The project investigates how aging HSCs become heterogeneous in function, examining reduced self-renewal capacity, myeloid-biased differentiation, and clonal hematopoiesis—a process in which mutated HSCs expand and have been associated with increased cardiovascular disease and cancer risk. The work will characterize how inflammation modifies HSC and clonal HSC function, and seeks to identify whether myeloid-biased HSCs expand in older humans and whether they can be depleted to restore balanced hematopoiesis. Performance occurs in Palo Alto, California through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $165.9k | 8/4/26 |