Project Grant K99AG097894
- The National Institute on Aging awarded Dana-Farber Cancer Institute, Inc. $1,526,573 on July 15, 2026, under the Aging Research program (CFDA 93.866) to conduct research on rejuvenation of aged hematopoietic stem cells and bone marrow niche function via mitochondrial engineering. The research addresses how aging impairs hematopoietic stem cell (HSC) transplantation success by driving mitochondrial dysfunction in donor cells. The work investigates mitochondrial transfer between HSCs and...
- The National Institute on Aging awarded Dana-Farber Cancer Institute, Inc. $737,261 on July 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the functional consequences of germline-encoded telomere dysfunction and its role in age-related disease. The award funds research applying functional genomics to elucidate how rare variants in telomere maintenance genes affect telomere length and drive age-related cellular dysfunction and disease. The study combines genetic approaches...
- The National Institute on Aging awarded The Leland Stanford Junior University $165,887 on August 5, 2026, under the Aging Research program (CFDA 93.866) to conduct research on human adult hematopoietic stem cells through aging, inflammation, and clonal selection. The research addresses functional changes in aging hematopoietic stem cells (HSCs) and their role in maintaining blood cell production. The project investigates how aging HSCs become heterogeneous in function, examining reduced...
- The National Institute on Aging awarded the University of California, Berkeley $598,837 on August 15, 2026, under the Aging Research program (CFDA 93.866) to investigate how hematopoietic stem cell aging affects distant tissues and organismal aging. The research will characterize a mouse model that reverses hematopoietic stem cell (HSC) aging by measuring changes in healthspan and lifespan and deciphering the molecular and cellular mechanisms underlying those alterations. The work tests the...
- The National Institute on Aging awarded Massachusetts Institute of Technology $723,962 on June 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a systems-level analysis of DNA damage and repair in senescence, aging, and cancer. The research applies mass spectrometric adductomics and an in vivo host cell reactivation assay to define the spectrum of DNA adducts in human cells, identify adducts that accumulate in senescing cells and drive replication stress, assess how...
- The National Institute on Aging awarded the President and Fellows of Harvard College $125,901 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a universal toolkit for single-cell somatic mutation detection and apply it to aging-related processes. The project addresses the challenge of detecting post-zygotic somatic mutations that accumulate throughout life and may contribute to aging and disease. While single-cell whole genome sequencing and duplex sequencing...
- The National Institute on Aging awarded Fred Hutchinson Cancer Center $1,571,734 on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate clonal hematopoiesis of indeterminate potential in aging and exceptional longevity in older women. The recipient will conduct epidemiological and mechanistic research on CHIP, an age-related blood cell mutation phenomenon, using approximately 10,000 older women from the Women's Health Initiative cohort, including roughly 7,000 with...
- The National Institute on Aging awarded Vanderbilt University $105,627 under the Aging Research program (CFDA 93.866) on August 5, 2026, to support an F30 predoctoral fellowship investigating how somatic mutations in hematopoietic stem cells contribute to aging-related diseases through clonal expansion of mutated blood cells. The research focuses on mosaic chromosomal alterations (MCAs), large-scale mutations linked to lymphoid malignancies and infection susceptibility. Aim 1 examines the...
- The National Institute on Aging awarded University of Massachusetts Medical School $626,409 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how aging impairs wound healing through hematopoietic stem cell dysfunction. The research uses single-cell epigenomics to characterize how aging affects gene expression of individual immune cells and the epigenetic modifications that regulate that expression. The project addresses whether aging impairs cutaneous wound...
- The National Institute on Aging awarded Beth Israel Deaconess Medical Center, Inc. $761,496 on June 15, 2026, to investigate epigenetic mechanisms linking delirium and cognitive decline under the Aging Research program (CFDA 93.866). The recipient will test the hypothesis that epigenetic risk, measured by DNA methylation, identifies individuals with a vulnerable brain predisposed to delirium, cognitive decline, and Alzheimer's disease and Alzheimer's disease-related dementias in the setting of...
The National Institute on Aging awarded Dana-Farber Cancer Institute, Inc. $130,680 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic drivers of stem cell fitness in aging hematopoiesis. The research elucidates how disrupted DNA methylation drives the defective inflammatory response of TET2-mutant hematopoietic stem cells under chronic IL-6 treatment and contributes to their enhanced fitness in aging populations. Over 75% of individuals aged 70 and older carry hematopoietic stem cells with leukemia-associated somatic mutations, a phenomenon known as clonal hematopoiesis; the proposal addresses mechanisms by which methylation changes permit expansion of TET2-mutant stem cells under age-associated inflammation. Specific aims include determining how DNA methylation controls inflammatory gene expression in TET2-knockout hematopoietic stem cells by defining and manipulating cis-regulatory regions governing their transcription; characterizing epigenetic clones that preferentially expand under chronic inflammation using high-throughput single-cell methylation technology; and addressing the causal role of DNA methylation in driving hematopoietic stem cell fitness through targeted DNA methylation editing. The training phase (K99) encompasses Aim 1 and part of Aim 2; the independent phase (R00) encompasses parts of Aim 2 and all of Aim 3. Performance occurs in Boston, Massachusetts, with a period of performance ending July 31, 2028. The award is classified as a Project Grant, a standard assistance type under the National Institute on Aging.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $130.7k | 8/4/26 |