Project Grant R01AG094122
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Jackson Laboratory $486,750 under the Aging Research program (CFDA 93.866) on September 1, 2025, for a two-year project period concluding August 31, 2027. The award supports research investigating the impact of age-related clonal hematopoiesis (CH) on Alzheimer's disease (AD) pathology and progression. The project aims to establish whether functional changes in peripheral immune cells resulting from somatic...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Virginia a $522,167 Project Grant effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866) to investigate the mechanisms of ribosomal DNA (rDNA) instability during aging. The research will employ innovative whole-genome double-strand break (DSB) mapping technology to examine how the FOB1 and UAF (upstream activation factor) proteins regulate rDNA copy number...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston Children's Hospital a Project Grant of $132,705.00 (awarded June 15, 2025; completion date May 31, 2027) under the Aging Research program (CFDA 93.866) to investigate metabolic vulnerabilities in hematopoietic stem and progenitor cells (HSPCs) during aging. The research addresses the decline in blood system function with age, specifically examining how metabolic heterogeneity among HSPCs contributes to...
- Federal Grant Award Summary The National Institute on Aging awarded a $610,836 Project Grant to the Broad Institute of MIT and Harvard (effective September 1, 2025, through May 31, 2030) under the Aging Research program (CFDA 93.866) to conduct systematic genetic research on mitonuclear interactions in aging and neurodegenerative diseases. The research will leverage two technological advances—mitochondrial DNA (mtDNA) editing using DDCBE base editors and biobank-scale analysis of mtDNA copy...
- Federal Grant Award Summary The National Institute on Aging awarded a $3.1 million Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh, with performance extending from September 1, 2025 through August 31, 2029. This research project investigates the beneficial immune response mechanisms triggered by persistent DNA damage in aging and age-related disease contexts. Specifically, the research examines how NLRP12 (NOD-Like Receptor 12), a member of the NLR...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $852,273 to The Trustees of Columbia University in the City of New York, Health Sciences Division, through the Aging Research program (CFDA 93.866) on September 1, 2025, for a project extending through May 31, 2030. This Project Grant funds a comprehensive genetic mapping study investigating the role of RNA modifications—specifically N6-methyladenosine (M6A) and pseudouridine (Ps)—in Alzheimer's disease (AD) pathogenesis...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Massachusetts Medical School $460,625 on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct a two-year research project concluding April 30, 2027. This project grant supports biomedical research investigating the role of Mixed Lineage Kinase Domain Like Pseudokinase (MLKL) in platelet-mediated immune responses during respiratory viral infections in older adults. The research...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a $1,072,936 Project Grant to the University of California, San Diego to conduct research on protein aggregation mechanisms in hematopoietic stem cells (HSCs) and their relationship to cellular aging. The award, effective September 15, 2025, with a completion date of June 30, 2029, funds investigative work under the Cardiovascular Diseases Research program (CFDA 93.837). The research will be...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $134,325 Project Grant to Weill Medical College of Cornell University on August 15, 2025, under the Aging Research program (CFDA 93.866). The award supports biomedical research investigating the role of calvarial skeletal stem cells in modulating neuroinflammation and immune cell infiltration in Alzheimer's disease (AD). The project, with a completion date of May 31, 2027, will examine a novel bone-brain axis mechanism...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Rhode Island a Project Grant of $567,224 under the Aging Research program (CFDA 93.866) for the period February 1, 2026 through January 31, 2031. This award supports research investigating tissue-specific modulation of mitochondrial DNA (mtDNA) mutations and their role in aging and age-related diseases. The study will utilize genetic approaches and a specialized mouse model to examine the mechanisms by...
The National Institute on Aging (NIA) awarded a $664,971 Project Grant to the University of Vermont & State Agricultural College on February 15, 2026, under the Aging Research program (CFDA 93.866). This longitudinal research initiative will investigate the longitudinal impact of clonal hematopoiesis (CH)—abnormal expansion of blood-forming cell clones in otherwise healthy individuals—on aging-related health outcomes and risk prediction through November 30, 2030. The research will measure CH in 30,239 participants from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study at baseline and approximately nine years later to establish clonal dynamics and identify potential intervention targets. The project delivers three primary research products: (1) characterization of baseline risk factors for CH in the diverse REGARDS cohort, including germline genetic factors; (2) prospective identification of risk factors for CH incidence and progression; and (3) establishment of CH's contribution and causality to adverse age-related outcomes including mortality, cognitive decline, coronary heart disease, stroke, heart failure, cancer, and cardiovascular risk factors. The biracial and geographically diverse REGARDS cohort population enables novel insights into the etiology, epidemiology, and consequences of CH across representative populations, advancing understanding of age-related disease mechanisms.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $665.0k | 2/5/26 |