This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $859,704 to support research on how the endoplasmic reticulum (ER) protein AGR2 regulates host-microbe interactions and inflammatory responses in Crohn's disease. The research aims to elucidate the cellular and molecular mechanisms by which AGR2 deficiency leads to ER stress, bacterial dysbiosis, and...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,312,002.00 to the University of Illinois for a research project titled "Plasticity of Type 3 Innate Lymphoid Cells Regulated by Intestinal Microenvironment." The award period runs from June 1, 2025 to March 31, 2030. The key objectives of this research project are to:...
This Project Grant award of $117,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of substance P-mediated activation of mast cells in driving visceral hypersensitivity and barrier dysfunction in irritable bowel syndrome (IBS). The objective is to delineate the underlying mechanisms of bidirectional crosstalk between sensory...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $228,948.00 to Weill Medical College of Cornell University to investigate how the neuropeptide adrenomedullin 2 (ADM2) regulates intestinal inflammation and tissue protection through its effects on group 2 innate lymphoid cells (ILC2s). The research aims to: 1) Test if enteric neurons modulate ADM2 expression...
This federal Project Grant award of $151,643, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on developing and evaluating Proteolysis Targeting Chimeras (PROTACs) to stabilize hypoxia-inducible factors (HIFs) as a potential therapeutic approach for inflammatory bowel disease (IBD). The principal investigator, Dr. Ornelas Sanchez, and his...
This Project Grant award of $758,542 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research supports research to determine the protective functional impact mediated by the protein POP3 on intestinal homeostasis and inflammatory bowel disease (IBD). The research aims to elucidate the underlying molecular mechanisms by which POP3 promotes a unique type I interferon signature to shape the...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $516,648 to The Leland Stanford Junior University to conduct research on understanding the mechanisms by which microbially derived metabolites regulate host gut inflammation. The award period runs from August 28, 2024 to February 28, 2027. The research aims to determine the regulatory...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totaling $1,007,304 supports research to investigate how genetic variants associated with inflammatory bowel diseases (IBD) affect the function of pathogenic T helper 17 (Th17) cells. The research aims to: Use massively parallel reporter assays (MPRAs) to identify putatively causal IBD variants within the accessible...
This federal Project Grant award of $524,837 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is supporting research to investigate the role of enteric glial mechanotransduction and the impact of mechanical stress on postoperative ileus (POI) and postoperative gastrointestinal dysfunction (POGD). The research aims to better understand the pathogenic mechanisms of POI in...
This Project Grant award of $467,200.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Baylor College of Medicine to conduct high-throughput functional analyses of genetic drivers of inflammatory bowel disease (IBD). The research aims to 1) screen and characterize IBD risk genes in a C. elegans microbiome model, and 2) validate IBD risk alleles in human intestinal...