This Project Grant award of $654,910 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to identify the molecular mechanisms underlying the contribution of cerebrovascular disease (CVD) pathologies to Alzheimer's disease and related dementias (AD/ADRD) in older adults. The award supports research at Rush University Medical Center to generate and analyze transcriptomic and proteomic data from white matter tissue samples, complementing existing data from gray matter. This...
This $6,226,692 project grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support research to examine the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the development of Alzheimer's disease (AD). The primary focus is on investigating how modifications in brain activity, particularly in the locus coeruleus (LC) and hippocampus (HPC) regions, can lead to the key pathological hallmarks of AD....
This $839,262 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a multilevel investigation into the effects of migration on the risk of Alzheimer's disease and related dementias (ADRD) among Mexican Americans. Conducted by the Trustees of Columbia University, the study will leverage a unique binational dataset to (1) estimate the impact of migration, US residence, and acculturation on cognitive function and dementia risk, (2) evaluate how...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support Emory University's research into the genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The $528,876 award, effective June 1, 2025, will fund the development of new analytic tools to integrate genomic data across multiple tissues and improve the identification of genetic risk factors and underlying molecular mechanisms for...
The National Institute on Aging (NIA), part of the National Institutes of Health within the Department of Health and Human Services, awarded a $2,567,371 Project Grant to The Trustees of Columbia University in the City of New York under the Aging Research program (CFDA 93.866). The grant will fund research from May 1, 2022 to April 30, 2025 to identify cell type-specific autonomous and non-autonomous interactions in Alzheimer's disease (AD) using induced pluripotent stem cell (iPSC) lines from...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $146,922 to The Trustees of Columbia University in the City of New York to conduct research on the impact of Alzheimer's disease on genetic signatures of hippocampal memory traces. The key objectives are to determine the gene expression landscape that distinguishes memory-encoding cells from memory-retrieval cells, and how this landscape changes with age and...
This Project Grant award of $3,462,615 from the National Institute on Aging (under CFDA Program 93.866 - Aging Research) supports a multi-year research project by The Trustees of Columbia University in New York. The goal is to construct a "multi-organ chart" (referred to as MAE) using advanced AI/ML techniques and large-scale multi-omics data to model the cross-organ biological and pathological effects underlying Alzheimer's disease and aging. The expected outcomes are to establish a...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund the development of a pulse-labeling assay to track extracellular vesicle (EV) secretion and spreading in the mouse brain. The $452,375 award, spanning Sep 2024 to May 2026, will enable the grantee, The Trustees of Columbia University, to create a tool called the HaloTag EV Pulse-Chase (HEVPL) assay. This assay will use AAV delivery, cell-specific promoters, and fluorescent labeling to visualize...
This Project Grant award of $2,557,260.00 from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will support a longitudinal study to investigate the transition from midlife to early late-life and the development of early clinical Alzheimer's disease and related dementias (AD/ADRD) among diverse populations. The study, led by the University of California, San Francisco, will conduct cognitive assessments and AD/ADRD adjudication on participants in the...
This $1,505,109 Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to identify undiagnosed Alzheimer's disease (AD) in non-Hispanic White, Hispanic/Latino, and non-Hispanic African American populations. The project will leverage electronic health records and genetic data to develop disease trajectory models and polygenic risk scores to detect undiagnosed AD, while addressing the issue of underdiagnosis in underserved...