Project Grant R01AG085518

Award Date 9/15/24
Completion Date 6/30/29
Dollars Obligated $767K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90095, USA
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This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $769,710 to the University of California, Los Angeles (UCLA) to conduct research examining the impact of socioeconomic mobility opportunities during adolescence on the development of Alzheimer's disease (AD) risk factors in young adulthood. The study will leverage the existing Reducing Inequities through Social and Educational Change Follow-up (RISE-UP) cohort to assess how mobility...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), supports a $424,184 research project titled "Alzheimer's Special Care Units in Nursing Homes: Racial and Ethnic Disparities, Resident Outcomes, and State Policies". The project aims to: 1) Examine disparities in access to Alzheimer's Special Care Units (SCUs) among Black and Hispanic residents with Alzheimer's disease and related dementias (ADRD); 2) Understand SCU access as...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to assess cost and non-cost barriers to the use of novel Alzheimer's disease (AD) and related dementias (ADRD) therapeutics among older Hispanic or Latino adults. The $311,341 award will fund a two-phase project. The first planning phase will involve semi-structured interviews with Latino adults and patients with AD/ADRD and their caregivers to inform a subsequent population-based survey through the...
The federal Project Grant award R01AG089512, titled "Discovering Heterogeneous Causal Pathophysiology of Alzheimer's Disease", is funded by the National Institute on Aging (CFDA 93.866 Aging Research) in the amount of $372,690. The award will be utilized by the University of California, Berkeley to undertake a comprehensive investigation into the heterogeneous causal factors underlying the progression of Alzheimer's disease (AD). The key objectives include: (1) developing novel...
This $1,205,827 Project Grant, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), will examine the role of environmental exposures as a risk factor for Alzheimer's disease (AD) among non-Hispanic Whites, African Americans, and Mexican Americans. The project will utilize blood samples from 3,000 participants in the ongoing Health & Aging Brain Study - Health Disparities Study to investigate the "exposome" and its impact on AD development within these...
The National Institute on Aging (NIA) awarded a $661,016 Project Grant (CFDA 93.866 - Aging Research) to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" platform. This project aims to leverage innovative artificial intelligence (AI) techniques and distributed computing to analyze Alzheimer's disease (AD) biobanks from the U.S., India, Japan, and Europe, totaling over 100,000 MRI and PET scans. The key...
This $2,557,260 project grant was awarded by the National Institutes of Health's National Institute on Aging (CFDA 93.866 - Aging Research) to The Regents of the University of California, San Francisco (UCSF) to conduct research on the lifecycle predictors and mechanisms of early Alzheimer's disease and related dementias (ADRD) among Black and White adults in their 60s. The key objectives of the 5-year project are to: 1) investigate the midlife to early late-life transition to clinical ADRD,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $751,442 to the University of California, Los Angeles (UCLA) to develop and evaluate a brain-permeable CRISPR-based gene editing therapy for Alzheimer's disease (AD). The key products/services include: Optimizing a microfluidic synthetic exosome (SE) system to deliver CRISPR components that can edit the APOE4 gene, a major genetic risk factor for sporadic AD, to the less pathogenic APOE3...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $778,499 to the University of Texas Health Science Center at Houston to develop novel machine learning models to identify and stratify heterogeneous subpopulations of Alzheimer's disease (AD) patients based on risk and progression patterns. The goal is to transform these subtypes into potentially targetable groups to enable focused clinical trials, support future therapeutic development, and...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,251,070 to the University of California Irvine through July 2025. The grant supports research to develop new statistical methodologies for analyzing Alzheimer's disease data from longitudinal cohort studies. Key deliverables include methods for assessing prediction precision for recurrent event survival data using time-dependent ROC and C-index...

This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $767,193 to the University of California, Los Angeles (UCLA) to identify undiagnosed Alzheimer's disease (AD) in underserved Hispanic/Latino and non-Hispanic African American populations. The key objectives are to:

  1. Identify disease trajectories associated with AD to help predict undiagnosed cases, while accounting for underdiagnosis bias in these populations.
  2. Integrate polygenic risk scores with the disease trajectory analysis to further enhance detection of undiagnosed AD.

The project will validate the predictive models and replicate the findings in the All of Us research program. UCLA is collaborating with the University of Pennsylvania, which is providing expertise in AD genetic epidemiology, polygenic risk score development, and result interpretation. The award period is from September 15, 2024 to June 30, 2029.

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