The National Institute on Aging (NIA), part of the National Institutes of Health within the Department of Health and Human Services, awarded a $2,567,371 Project Grant to The Trustees of Columbia University in the City of New York under the Aging Research program (CFDA 93.866). The grant will fund research from May 1, 2022 to April 30, 2025 to identify cell type-specific autonomous and non-autonomous interactions in Alzheimer's disease (AD) using induced pluripotent stem cell (iPSC) lines from the Religious Orders Study/Memory and Aging Project. Columbia University will establish mixed in vitro co-cultures of neurons, astrocytes, and microglia differentiated from iPSCs representing donors with varying AD pathology and cognitive trajectories. Preliminary data shows concordance between in vitro and post-mortem data from donor monocultures. The mixed cultures will help discern cell type-specific changes driven autonomously versus induced non-autonomously through interactions. Researchers will profile differentiated cells using single-nucleus RNA sequencing and conduct functional assays to further understand convergent cell-type effects in AD. A $2,567,371 subaward to Brigham and Women's Hospital will support all in vitro experiments, differentiations, assays, and contributions from co-Principal Investigator Dr. Tracy Young-Pearse.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.6m | 4/19/22 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
1GG01511801S | Brigham & Womens Hospital Inc. | Project Grant RF1AG072167 | $1.6m | 8/30/24 | |
2GG01511801S | Rush University Medical Center | Project Grant RF1AG072167 | $29.2k | 8/29/24 |