Project Grant HT94252510676

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $236,566.00 to the University of Alabama at Birmingham (UAB) to investigate the contribution of circadian rhythm disruption to Duchenne muscular dystrophy (DMD) disease pathology. The research aims to evaluate the role of dystrophin expression in the skeletal muscle and...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,624 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Rutgers, The State University to conduct research on sleep and circadian rhythm disorders following traumatic brain injury (TBI). The project aims to use the Drosophila melanogaster genetic model to 1) identify genes that contribute to TBI-induced changes in sleep and circadian rhythms, and...

This federal Project Grant award for $443,736 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand how intercellular communication among circadian pacemaker neurons generates different phases of circadian output in the fruit fly model system Drosophila. The 5-year award, beginning on July 1, 2025, will test the hypothesis that distinct forms...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $451,250 to Childrens Hospital Medical Center in Cincinnati, Ohio to investigate the molecular basis of circadian and sensory integration in neuronal clocks. The research aims to elucidate how internal and external signals are integrated to coordinate clock gene expression within brain centers that regulate physiology and...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA program 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", provides $373,200.00 to the Regents of the University of Michigan to decipher the role of mRNA nuclear localization in circadian rhythms. The research aims to: 1) determine the sequences required for nuclear localization of the timeless (TIM) mRNA, a core clock gene, and 2)...

The federal Project Grant award R21NS136974 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $466,125 award to President and Fellows of Harvard College, doing business as Harvard Medical School, aims to analyze the composition of two BMAL1 circadian clock complexes purified from the mammalian brain and develop procedures for determining their...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $655,655 to Northwestern University to conduct research on the physiological and behavioral basis of Delayed Sleep-Wake Phase Disorder (DSWPD). The research aims to identify distinct DSWPD subtypes based on differences in circadian physiology and light sensitivity, in order to develop personalized treatment approaches. The study...

The National Institutes of Health's National Institute on Aging awarded a $2,366,184 Project Grant to The General Hospital Corporation, doing business as Massachusetts General Hospital, to support research into the mechanisms of circadian and synaptic dysfunction after repetitive mild traumatic brain injury. The three-year award, made on June 1, 2022 under the Aging Research program (CFDA 93.866), will fund work by Drs. Whalen and Lipton to define how interleukin-1 receptor 1-mediated...

This Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, will support research at Purdue University to investigate the connection between metabolic changes, epigenetic modifications, and circadian rhythm disruptions in Alzheimer's disease (AD). The $419,005 award, spanning May 2025 to April 2027, will focus on studying how changes in one-carbon metabolism and the ratio of S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) impact chromatin...

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $515,898 to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC) division to investigate the contribution of astrocytes and increased astrocyte calcium signaling to sleep impairments in Fragile X Syndrome (FXS). The research aims...