The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $515,898 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Nebraska Medical Center (UNMC). This 5-year grant, effective from April 1, 2025 to February 28, 2030, aims to investigate the contribution of astrocytes, a type of glial cell, to sleep/wake disturbances in Fragile X Syndrome (FXS) and Autism Spectrum Disorder (ASD). The research will longitudinally assess sleep architecture in FXS mouse models, measure cortical astrocyte calcium signaling dynamics during sleep-wake cycles, and determine the causal relationship between altered astrocyte calcium signaling and sleep impairments using genetic and chemogenetic approaches. This innovative, multifaceted study is expected to provide critical insights into the molecular and cellular mechanisms underlying sleep disturbances in FXS, which can inform the development of astrocyte-targeted therapies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $515.9k | 3/28/25 |